[BBB/Autism/Junk Sciences] Autism, bleach and the blood-brain barrier: how the CD/MMS cult is promoting child abuse on bogus scientific claims.

I have been blogging about quack medicine, charlatanisms and debunking claims about the blood-brain barrier for few years now. But nothing reach the level of indignation and anger than the treatment reserved for children diagnosed as “on the spectrum” (for autism spectrum disorder or ASD), especially those treated with the “CD/MMS protocol” aka “the bleach protocol”, as recently discussed in various blogs and in news outlet here and there.

Introduction:

“Autism spectrum disorders” that is an umbrella medical definition that is defining children presenting deficiencies in social skills, a particular focus on patterns or objects including certain rituals or organization (e.g. sorting toys by their colors, lining cars in a perfect order, bed linen to be perfectly folded), hyper-sensibility to environmental cues (sounds, light, colors….) and in some cases neurodevelopment or communication delays. Not all autistic children are equals, with very different types of syndromes or conditions (e.g. Asperger’s Syndrome, Rett’s Syndrome……).

Although the etiology of ASD is deeply anchored into genetics as a major risk factor (followed by neuroinflamamation during gestation due to infectious diseases), the diagnostic still remains flexible and have been standardized only recently through the “Diagnostic and Statistical Manual for Mental Disorders”, currently in the fifth edition. Such standardization is as recent that a notable number of adults often get diagnosed “on the spectrum” late in their life, often during their adulthood.

Until now, there is no therapies to address such condition and mostly involves medication for treating other conditions associated with the disease (epilepsy is often diagnosed in children on the spectrum) or behavioral therapy (also known as applied behavioral analysis).

Because the diagnosis of autism is perceived and feared amongst parents and the lack of therapies are obvious, such environment creates a fertile ground for charlatans and snake oil seller preying on fear to make profit, selling parents a “cure-it all” potion or interventions, using these children as “guinea-pigs” by pushing protocols or treatment that are best have poorly fared in the scientific literature (most of the time published in low-impact factor journals) if not completely bogus.

A few example of such doubtful or quack remedies are dietary restrictions (gluten-free/casein-free diets), injection of biologics (GcMAF), if not dangerous interventions such as the use of hyperbaric oxygen treatment or use of chelation therapy. But amongst them reside one of the worst treatment: the CD/MMS protocol, or as we should call it the “bleach protocol”.

The CD/MMS protocol: a fancy name for a bleach protocol targeting autistic children

CD stands for chlorine dioxide (O=Cl=O) a bleaching agent used mostly for industrial purposes. CD shares similarities with the household bleach (O=Cl-) and both as referred as chlorinated bleaching agents.

Until recently, Kerri Rivera has been actively promoting the CD/MMS protocol as a “cure for autism” through her book co-authored with other charlatans named “Healing The Symptoms Known As Autism”. in this book, they promote the use of CD via ingestion of droplets or via enema administration. Such aggressive chemical is enough to damage the mucosal layer lining the luminal wall of the gastrointestinal (GI) tract and its detachment. Such detached mucosal layer is often labelled as “parasites” which indeed any respected parasitologist will quickly debunk such fallacious claims.  Kerri Rivera promotes the use of this protocol to cure “autistic children” and up until recently was promoting such treatment in the Autism One conference. She discussed in details about this protocol on the Chapter 8 of her book and makes disturbing claims about the blood-brain barrier.

Fallacious things Kerri Rivera said about the blood-brain barrier in her book:

The first fallacious claim from Kerri Rivera appears on Chapter 3, pages 48 and 49. In this chapter, she promotes the gluten-free/casein-free/soy-free diet as a treatment for autism with the excuse of the “leaky gut syndrome” as the following: “This results in poor digestion, which facilitates the entry of these harmful proteins [gluten and casein] directly into the bloodstream, where they can cross the blood-brain barrier.“. I never heard about gluten and casein crossing the BBB, especially considering that these are large peptides and therefore have to use transporters and receptors. Of course, her claims is not backed by a reference to a study.
Then she refers to this ” Improperly digested gluten and casein fragments can both enter the bloodstream and cross the blood-brain barrier. Because of their opioid properties, these peptides can react with opiate receptors in the brain to cause effects similar to those of an opiate drug such as heroin or morphine.7 These opiates are called gluteomorphin (or gliadorphin) and casomorphin, and can react with some parts of the brain, for example, the temporal lobes, which are actively involved in the process of the integration of language and hearing. Interestingly, these are two of the areas most affected by autism.

She cites this page for her claims. Interestingly, if you look at the page this claim is based on making a parallel between celiac disease and a speculation and hypothesis as cited: “Now in terms of autism, the situation is somewhat different because children with autism generally do not have celiac disease and do not have the DQ2 genotype problem. Whereas the problem of celiac disease is well proven in scientific studies, the problem with gluten sensitivity in autism is less well studied. The autism hypothesis involves, like celiac disease, the toxic effects of small peptides, generally in the range of five to seven amino acids in length (termed casomorphin and gliadorphin, as noted below). It is believed that these peptides from gluten, as well as certain peptides from cow milk protein (casein), can somehow cross the intestinal microvillus barrier and reach the blood stream.”

In a previous edition, Rivera went further and cited two papers to back her claims (now this claims has been watered down and put in the FAQ section of this chapter):  a study from Reichelt1 and colleagues and a  review from Shattock and colleagues2. Firstly, the citation of Shattock review is outdated and only provide an exhaustive overview of published studies supporting or dismissing the theory of opioid-excess. It has no scientific value as it does not provide a direct evidence of such claim. More troublesome is the following study led by Hunter and colleagues published by Hunter and colleagues in 2003 investigating the presence of opioids mimetics in patients urine and published in Developmental Medicine & Child Neurology3, a journal with an acceptable impact factor (IF=3.29). Using liquid chromatography coupled with mass-spectrometry (a common analytical technique used for measuring metabolites in biological fluids), the authors have investigated the presence of opioids in a cohort of 10 children with ASD and used siblings as controls. Interestingly, the authors failed to notice notable differences (as defined by presence of unique peaks) in the urine chromatogram of ASD children compared to controls. The authors further investigated the presence of opoid peptides previously cited by Shattock, in particular beta-casomorphin (a peptide byproduct obtained from casein degradation) and alpha-gliadin (a peptide byproduct obtained from gluten degradation). The authors failed to identify the presence of both peptides, based on retention time compared to standard or based on the m/z index.  This publication irated enough Shattock to be followed  by a comment to Editor and a scientific joust between Shattock and Hunter4, however an  editorial published by John F Mantovani resumes well the context in which the initial statement of Shattock was published5. At this time, ASD etiology was completely unknown and remained highly speculative. The publication (and subsequent retraction) of the so-called “Wakefied study” 6 linking MMR vaccines to ASD cases, but also documenting the presence of inflammatory bowel disorder in ASD patients, such condition is known to triggered by gluten and casein in patients suffering from celiac diseases. As Mantovani mentioned, the adoption of the theory of gluten and casein was correlating with the same approach than the vaccine without any scientific rationale. The study from Hunter indeed showed the lack of evidence about the claim made by Shattock. The amount of studies linking autism and exorphin remains very low. A query on Pubmed (the database of the National Library of Medicine) using the keywords “autism” and “exorphin” results in only 7 publications with 3 publications from Reichelt, KL and two publications from Brudnak, MA.
This brings the concern of data reproducibility. In order to have a scientific claim that have strong significancy you need two factors: a significant number of publications that investigated such statement and the publications of findings from different research groups. Having the monopoly of such investigation solely on a single research laboratory raises the issue of data reproducibility and reliability.
In this case, the study of Reichelt is very interesting, as its publication quality appears dubious at different levels. The journal of Microbial Ecology and Health Disease has recently adopted the “open-access” policy. Prior its publication as open-access, the journal has an 2013 unofficial impact factor of 0.933. The “open access” and the low IF raise red flags: such journal may be a potential “predatory journal” (a term coined by Retractionwatch.org, a website tracking scientific articles retraction). In this model, the cost of open-access is levied by the payment of hefty publication fees ($3000-5000) usually higher than subscription-based journals. Because of such financial gain, the peer-review process may be altered and even may be completely omitted, removing the quality control accomplished by peer-review. This lack of peer-review process is particularly blatant by the absence of clearly structured “methods” sections, odd wordings for a scientific (“ELISA typed as Elisa, thaw over night, eight-hundred microliters”), the source of samples (Association Planet Autism (Italy), samples from Slovenia, Serbia and Australia) and the overall format of the paper figures with some appearing as a screenshoot of a Powerpoint presentation or from printed copies. It raises some skepticism about why the author (based in Norway) failed to collect samples from Norwegian ASD patients.

In the previous edition, Rivera linked these studies to a “leaky bowel syndrome”. A major flaw in this claim is the absence of citing the original publication for Hsaio and colleagues7 that have demonstrated the presence of a “leaky gut syndrome” in mice showing an ASD phenotype. Instead Rivera cites the Gluten Free Society webpage as a source of information (http://www.glutenfreesociety.org/gluten-free-society-blog/dr-fasano-on-leaky-gut-syndrome-and-gluten-sensitivity/).

Dr. Alessio Fasano is certainly a respected researcher in celiac diseases but as noted with pseudoscience and activists groups lacking the scientific knowledge, cherry-picking and extraordinary extrapolation. In particularly in this case by the Gluten Free Society, those as their Facebook webpage mentions, identify themselves as alternative and holistic health society. This is again a red flag on the mission and purpose of this society that have little or no scientific evidence to support their claims except deviating, cherry-picking and reformulating genuine studies to push for their agenda.

Under normal conditions, the intestinal and the blood-brain barrier (BBB) (Figure 1) provides a tight cell monolayer creating a gut-blood and a blood-brain barriers respectively. Under normal conditions, such barrier is achieved by the presence of tight junctions complexes stopping the diffusion of electrolytes and water between the two compartments. Only digestion byproducts such as amino-acids or glucose are transported through dedicated nutrient transporters or solute carriers, whereas bigger entities such as peptides, proteins and pathogens have virtually no diffusion). Only lipids (fatty acids, cholesterol…) and drugs (designed as lipid-soluble chemicals) can passively diffuse across the barrier by mixing themselves with the phospholipid bilayers making the cell membranes.

Picture1

In the study from Hsiao, the authors demonstrated indeed the presence of a “leaky gut” as measured by an increase in FITC-dextran permeability with an estimated size of 4kDa (that’s about the size of a peptide of 36 amino acids). Even is such peptides can cross a “leaky gut”, they still have to cross the BBB. Some scientific studies have demonstrated the biological activity of opioids analogs obtained from digestion byproducts, including gluten and casein. Yet, a review from Lister and colleagues 8 denoted that a majority of these studies were based on intracerebroventricular (ICV) injections (or intracranial). This drug delivery approach allows to bypass the BBB but also is a very invasive approach that is used in clinical settings only for emergency and severe cases.

If such peptides were to cross the BBB and exert the biological activity discussed by Rivera, they have to have a dedicated peptide transporter that can deliver such peptides from the blood to the brain side. The number of peptides capable to cross the BBB has been recently reviewed by Banks 9, a well-established BBB scientist in the transport and delivery of peptides and inflammatory cytokines across the BBB. There is no mention about any of the opioids mentioned by Reichelt or Shattock publications. Furthermore, the increase in gut permeability appears unlikely or indirectly related to gluten or casein-sensitivity, as the authors demonstrated a change in the gut microbioma, in particular changes in Bacteorides fragilis as well as changes in metabolites discovered in serum plasma. However this study has to be taken with a lot of precaution due to the differences related to interspecies variation, the behavioral representation of mice to model ASD and more importantly, similar studies in human patients investigating samples from stools and plasma levels to observe if similar trends or biomarkers are noted in humans.

The next chapter that talks about the BBB is the Chapter 5, in which she discussed about the use of CD/MMS protocol, claiming to hunt their imaginary parasite inside the brain as mentioned by the following: ” In early 2011, we added enemas to the protocol to kill the pathogens causing dysbiosis in the large intestine (we didn’t know about parasites yet). We wanted to get the chlorine dioxide into the blood stream so it could kill the biofilm that exists in the blood. In this way, the blood can carry the CD past the blood-brain barrier to kill pathogens in the brain
When we are detoxing, it is absolutely critical to keep the colon moving and avoid the reabsorption of toxins through the intestinal walls. Enemas allow us to do just this. Some toxins can exit the intestine through the intestinal wall (more so if leaky-gut syndrome is present), and cross the blood-brain barrier, therefore affecting cognition and behavior. When we cleanse the colon, we get those out before they can cross into the brain, and we detoxify the lymphatic system, liver, and gallbladder.
The following argumentation of Rivera is very interesting as she is referring to Dr. Andreas Kalcker and the parasites at the base of her bleaching-based therapy. Let’s first identify Dr. Kalcker. According to his official biography (http://www.andreaskalcker.com/en/biography.html), he studied economics in Barcelona and has earned a Ph.D. in biophysics and alternative health without mentioning his alma matter. This is very puzzling, as any genuine Ph.D. holder will mention the institution that granted his/her degree. Furthermore, the deliverance of a Ph.D. in biological and biomedical sciences (and I believe in any scientific domains) requires the publication of at least one publication in a peer-reviewed journal. Notably, the search of Dr. Kalcker publication in either Pubmed (NLM) or in Sciencedirect (Elsevier) database leads to inconclusive results. At this stage, his Ph.D. degree claim is highly doubtful and raises concern about the credentials of Andreas Kalcker to hold such title.
The main question that can arise is on which expertise Dr. Kalcker discusses about autism, parasites, blood-brain barrier and nutrition? The author of this critique has 11 years of scientific research experience in the blood-brain barrier, 15 peer-reviewed publications.
The gut-brain axis is still a fairly new concept in the BBB field. Up to now, there is only one study that have demonstrated the beneficial effects of gut microbioma on the BBB development during gestation 10 and requires more studies to further confirm this single report. Furthermore, ASD diagnosis and mechanisms of disease have highly progressed since the original retracted publication of Wakefield and colleagues. It is now a consensus that ASD is triggered by two major factors: a genetic and an environmental factor11-14.
The current consensus is the predominance of the genetic factor that set the risk of ASD development and different factors in particular exposure to environmental toxins may trigger the onset of the condition. This second aspect is very interesting, as the penetration of such toxins across the BBB is poorly understood and believed that the presence of efflux drug transporters and phase II metabolism enzymes would void the penetration of such compounds across the BBB and target neurons. Such statement is supported by the ability of the BBB to act as a very strong barrier towards xenobiotic (drugs and toxins), we estimate than less than 5% of current drugs are capable to cross the BBB. The presence of such BBB is a main challenge for drug delivery 15, 16. However, scientific literature yet has to demonstrate how such environmental polluants mar the BBB and how they may affect brain development during gestation that leads to the ASD onset.
Therefore, we can reasonably ask the following question:

  1. On which scientific basis Kelly Rivera supports the claim of parasitic infection? There is no published scientific literature supporting her claim.
  2. Furthermore, under which expertise and scientific literature Dr. Kalcker built his theory on the improper digestion?

According to the Merriam-Webster Dictionary (http://www.merriam-webster.com/dictionary/theory), the definition of theory is “the analysis of a set of facts in their relation to one another”. Neither Kerri Rivera nor Dr. Kalcker have the credential to set a theory because there is no scientific facts to support their theory.

Therefore their tentative to explain their rationale is deeply flawed and should be considered as wrong until a significant number of studies with the adequate scientific quality and neither Rivera or Dr. Kalcker have demonstrated the credentials to exercise a diagnosis or establish a treatment regimen and are legally unlicensed to practice medicine (diagnosis) or pharmacy (treatment) and may face severe legal issues to do so.

The most compelling fact of Rivera and Dr. Kalcker are their active participation in the sell of MMS and CD as a treatment from autism. Such behavior is a clear sign of conflict of interest, a modern form of snake oil sell and a deliberate act of poisoning. Such misuse of public trust and poisoning has lead to the arrest of Dr. Kalcker in Spain in 2014 as reported by the bancdmms website (http://www.bancdmms.com/#!about1/c157n) as well as pro-MMS groups.

In conclusion, until now there is not direct evidence of a gut-brain axis interaction triggering ASD is until now a fallacious statement. There is no clear evidence of such statement, only a series of meticulous cherry picking studies from predatory journals and retracted articles. The direct evidence of gluten and casein peptides in ASD patients is weak and doubtful and would requires a substantial re-evaluation of such claims until other independents research groups demonstrates similar outcomes under controlled conditions.

Furthermore, the etiology of ASD as presented by Rivera and Dr. Kalcker is pure fallacy as none of them have the expertise, credentials and the scientific evidence to make such claims but also have deliberately ignored a sustained and solid publication records concerning the diffusion of peptides across the BBB and the etiology of ASD as a neurological disorder with a high genetic background (supplemented by an environmental factors).

Because the etiology of ASD at this time remains elusive, the treatment of ASD by medication remains until now undocumented, even using pre-clinical models. Only an early diagnosis and intervention by behavioral therapy have been proven successful to improve behavioral and social outcome in ASD patients.

Using common tactics of pseudoscience to distract a non-scientific literate audience, Rivera shows her ability to build an argument on fallacious statements with a an obvious conflict of interest (the endpoint is to sell her MMS/CD cure), as well as a documented harmful outcome of such treatment.

References:

  1. Reichelt KL, Tveiten D, Knivsberg AM, Bronstad G. Peptides’ role in autism with emphasis on exorphins. Microb Ecol Health Dis 2012; 23.
  2. Shattock P, Whiteley P. Biochemical aspects in autism spectrum disorders: updating the opioid-excess theory and presenting new opportunities for biomedical intervention. Expert Opin Ther Targets 2002; 6(2): 175-83.
  3. Hunter LC, O’Hare A, Herron WJ, Fisher LA, Jones GE. Opioid peptides and dipeptidyl peptidase in autism. Dev Med Child Neurol 2003; 45(2): 121-8.
  4. Shattock P, Hooper M, Waring R. Opioid peptides and dipeptidyl peptidase in autism. Developmental Medicine & Child Neurology 2004; 46(05).
  5. Mantovani JF. Not knowing. Developmental Medicine & Child Neurology 2003; 45(02).
  6. Wakefield AJ, Murch SH, Anthony A, Linnell J, Casson DM, Malik M et al. Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children. Lancet 1998; 351(9103): 637-41.
  7. Hsiao EY, McBride SW, Hsien S, Sharon G, Hyde ER, McCue T et al. Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Cell 2013; 155(7): 1451-63.
  8. Lister J, Fletcher PJ, Nobrega JN, Remington G. Behavioral effects of food-derived opioid-like peptides in rodents: Implications for schizophrenia? Pharmacol Biochem Behav 2015.
  9. Banks WA. Peptides and the blood-brain barrier. Peptides 2015.
  10. Braniste V, Al-Asmakh M, Kowal C, Anuar F, Abbaspour A, Toth M et al. The gut microbiota influences blood-brain barrier permeability in mice. Sci Transl Med 2014; 6(263): 263ra158.
  11. Fakhoury M. Autistic spectrum disorders: A review of clinical features, theories and diagnosis. Int J Dev Neurosci 2015.
  12. Correia C, Oliveira G, Vicente AM. Protein interaction networks reveal novel autism risk genes within GWAS statistical noise. PloS one 2014; 9(11): e112399.
  13. Pinto D, Delaby E, Merico D, Barbosa M, Merikangas A, Klei L et al. Convergence of genes and cellular pathways dysregulated in autism spectrum disorders. American journal of human genetics 2014; 94(5): 677-94.
  14. Rossignol DA, Genuis SJ, Frye RE. Environmental toxicants and autism spectrum disorders: a systematic review. Transl Psychiatry 2014; 4: e360.
  15. Cucullo L, Aumayr B, Rapp E, Janigro D. Drug delivery and in vitro models of the blood-brain barrier. Curr Opin Drug Discov Devel 2005; 8(1): 89-99.
  16. Abbott NJ. Blood-brain barrier structure and function and the challenges for CNS drug delivery. Journal of inherited metabolic disease 2013; 36(3): 437-49.

 

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[BBB/Sciences] Study on a iPSC-derived model of the blood-brain barrier inclusive of astrocytes, neurons and pericytes retracted.

According to RetractionWatch “an investigation by Kyoto University in Japan has found a researcher guilty of falsifying all but one of the figures in a 2017 stem cell paper. Yesterday, Kyoto University announced that the paper’s first author, Kohei Yamamizu, had fabricated and falsified data in the Stem Cell Reports paper.

I remember reading this paper (http://www.cell.com/stem-cell-reports/fulltext/S2213-6711(17)30039-5) last year with my student. We found it interesting but also odd and with several caveats. Turned out that almost every figures have been doused with falsified or manipulated data.

First time I see a paper in our field being retracted for scientific fraud. Wow.

Source: Researcher at Japan stem cell institute falsified nearly all images in 2017 paper – Retraction Watch at Retraction Watch

[Science/BBB] Zakłócenie bariery krew-mózg wywołane histaminą u dzieci ząbkujących: błąd logiczny.

[Note] I am not a Polish speaker, so I would like to thanks a follower from Poland (Ania D) for the translation of my blog post. 
This is a special translation for Polish readers of one my previous blog post ([Sciences/BBB] Histamine-induced blood-brain barrier disruption in teething children: a “post hoc ergo” on glucocorticoids.). I got informed that a certain Polish anti-vaxxer group used that same blog post to make fallacious claims on histamine and the blood-brain barrier, using my post as a “source” for their claims as depicted below (look at the citation on the bottom line).

27335428_1824421747569071_1901568509_o

Not only their allegations are false, but they also failed to check their citations to their claims. A respectable person making a claim checks his/her sources, especially when such claims are completely nullified by the source. Here goes the translation in Polish.

Niedawno dotarła do mnie informacja, o tym, że mój artykuł został podlinkowany pod memem, w którym pojawia się informacja o tym, że ząbkowanie powoduje rozszczelnienie się bariery krew-mózg, a to z kolei stanowi przeszkodę w wykonaniu szczepień. Czy jest to prawda? Oczywiście nie. Chciałbym teraz w kilku zdaniach wyjaśnić dlaczego jest to kłamstwem. Po pierwsze, ząbkowanie (lub erupcja zębów) jest procesem obejmującym zapalenie dziąseł: są czerwone, gorące i opuchnięte, w trakcie tego procesu uwalniane jest wiele różnych substancji chemicznych, które wywołają to, co nazywamy odpowiedzią zapalną, m.in.histamina- uwalniana miejscowo, w ognisku zapalnym. To daje nam prosty wniosek- jedyną możliwością, żeby histamina naruszyła barierę krew- mózg (BBB) jest pojawienie się zębów w mózgu, a to o ile mi wiadomo nie jest możliwe.
Po drugie, załóżmy na chwilę, że to twierdzenie jest prawdą, załóżmy, że histamina może się gromadzić i osiągać stężenie na tyle wysokie, aby spowodowało to zakłócenie BBB.
Do chwili obecnej sprawdzenia poprawności tej tezy podjęto się tylko dwa razy, ponad 40 lat temu, w dziennikach medycznych z Brazylii i Egiptu, które raczej nie są wiodącymi pismami w swojej dziedzinie. Zobaczmy zatem, jaka jest reakcja immunologiczna, w odpowiedzi na uwalnienie dużej ilości histaminy:
https://www.sciencedirect.com/science/article/pii/S0091674900321704?via%3Dihub#aep-table-id22
Mierzony był poziomy histaminy u pacjentów z szokiem alergicznym, jednak żaden z nich nie wykazał zakłócenia BBB. Najwyższy osiągnięty poziom histaminy wynosił około 30 nmoli / L (warto zapamiętać tę liczbę!). Czy zatem możliwe jest, że w przeciwieństwie do szoku, ząbkowanie mogłoby otworzyć barierę krew- mózg? Nie. Od razu zaznaczę, że rozwój BBB następuje u płodu w drugim trymestrze, więc nie ma tu zastosowania argument, o niedojrzałości bariery krew- mózg ( https://www.frontiersin.org/articles/10.3389/fnins.2014.00404/full )
Pojęcie “przeciekania lub niedojrzałości BBB” u niemowląt jest przestarzałe i nie jest już podtrzymywane przez społeczność naukową

Po trzecie, w badaniach potwierdzających możliwość otwarcia BBB przez histaminę jej stężenie było na poziomie między 10 mikromoli / L, a 100 mikromoli / L
( https://www.ncbi.nlm.nih.gov/pubmed/1611469
https://www.ncbi.nlm.nih.gov/pubmed/9379415 ).
Ponieważ 1 mikromol / L jest równy 1000 nmoli / L, prosta matematyka daje nam wniosek, że potrzebna do naruszenia bariery krew- mózg reakcja jest 300- 3000 razy silniejsza niż reakcja wywołana u osób z reakcją alergiczną na histaminę.

Nie daj się zwieść memom, zawsze sprawdzaj źródło użyte do poparcia roszczeń. Teraz możesz śmiać się z tego głupiego mema i głupiej osoby, która udostępniła mój link bez czytania oryginalnego posta na blogu. Ten meme został stworzony przez polskie antyszczepionkowe stowarzyszenie StopNop. Informacja na tym memie jest nieprawidłowa i nie zgadza się z treścią cytowanego artykułu.

 

[SciFi/Star Wars] Star Wars: The Last Jedi (Episode 8) (80%)

Star Wars: The Last Jedi came out about a month ago and I think that now after two views (distanced by about two weeks),  I can finally write down a final opinion on it. What I can tell, it created some serious divide between the critics and fans. Just look at the difference in scores in Rotten Tomatoes between critics (that lauded it) and fans (that some claims is even worse than Attack of The Clones).
So far, the best and most interesting fan review came from Kevin Smith. A very good hour in which he goes through details, highlighting the good and underlining the bad things about.
I decided to give it a few weeks before making my comments for one reason: the Jedi mind trick that hit me 15 years ago when Attack of the Clones came in screen. At first, I was “Oh yeah, it was awesome! One of the best Star Wars!” and still remember the diatribe from Rafic Djoumni, a former journalist in “Mad-Movies” (a well-respected French magazine about Sci-Fi and horror movies that was my favorite movies magazine). Looking back, the movie honestly did not survived the tides of time and is needed not as good as I remember (please someone remove Anakin meadow scene from my brain!).
ATTENTION————————SPOILERS AHEAD! YOU ARE WARNED!———————————-
So, there is the deal: the movie is good, better that was fans try to make you believe. But it is also not the masterpiece sold by critics. No, it is not “The Empire Strikes Back” quality (still awesome after thousands of watching and almost 40 years in the odometer). There are some good moments, and there are also just scenes I would have cut and I would not even notice I was missing something in the story plot. I feel Rian Johnson wanted to not follow the same steps than JJ Abrams and thought probably it was time for  his own vision of a trilogy. Although this can be a laudable move, it also meant that a lot of things brought by JJ went under the rug.
The movie starts with a bang, right where we kind of left it “The Force Awakens” and it is very intense. Imagine a WW2 bombing operation transposed in a galaxy far far away a long time ago. It was starting very well, but then started to stall at some point. The Rebels try to escape from the Imperial Fleet, only to be caught up a few hours after jumping out from Hyperspace. If you are accustomed to the reboot of “Battlestar Galactica” aka “BSG”, the plot of the first episodes named “33”. I don’t want to spoil much (because this is one of the most awesome Sci-Fi franchise from the mid-2000s I wished was aired in FrenchTV back then) as the Cylons are capable to track “the 12 colonies of Kobol” surviving fleet each time they jump from their FTL (faster than light) drive. Each time after 33 minutes.
This creates a plot in which the Rebels are in a sort of face-off, running out of fuel. Thats sounds a good plot but then you realize it runs on a paper thin. The Imperial fleet has a formidable firepower that would zap the fleet. No, they just stand waiting them to run out of fuel. Kylo Ren is keeping on the rage, only to be disciplined by Snokes. Enough to have Kylo to pick a Tie fighter and attempt a suicide mission on the main fleet vessel carrying General Leia Organa. He literally blew the ships deck with Admiral Ackbar in it sending Leia floating in space. This is where we have another ridiculous scene with CGI as good as “The Matrix Reloaded” (the infamous Playstation2 CGI). One of the sequence I liked however was the appearance of Laura Dern as Admiral Hodo. I was waiting for the “Fuck You, Poe!”, as I am still in all my Twin Peaks mindset and seeing Laura Dern playing the Diane tulpa. Her last move was a last kind of bravado act, going down with her ship as any respectable Captain do after ordering the crew to abandon ship (I almost felt Star Wars was getting inspiration from Trek). The whole sequence was simply a shock and awe, with a complete silence during the scene (remember…….in space nobody hear you scream!).
This scene is enough to questioning where Johnson wants to bring us. I guess it was meant to ramp into the sub-plot of the “Casino planet” that I thought was 45 minutes of major meaning. So I will skip this and go to Lukes plot. We left that with Rey finding Luke and handing him over his lightsaber, the same one he lost on Bespin in the Empire Strikes Back. Here comes the funny part that I liked about, seeing Mark Hamill throwing away the lightsaber and basically saying “enough of this BS”. I liked this whole sub-plot except the Porgs and the nuns. I felt seeing this part of the story was very good and show how the Jedi Council behind his allure of virtue and nobility are not as clean as they want to make things look like. They have sinned in their own way by their overconfidence and maybe also their inability to evolve. Seeing Yoda as a puppet was also a touching moment.
Rey rejoins the whole group and decide to confront Snoke. This is just bringing the second anti-climatic phase of the movie. Snoke dies like an idiot, Captain Phasma dies like an idiot. Both getting the Bobba Fett Mary Sue treatment. Both flattened out as a missed souffle. So we have been waiting two years for something that felt flat like a deflated balloon?
The last quarter of the movie was kind of awesome. It was somehow replaying the plot of the Battle of the Hott system. Seeing the evolved AT-AT and seeing the Rebels cornered brought in this level of stress that was initially here. Then came Luke (sort of), almost coming as a Messiah. And Hell he looked like the Chosen One in a scene reminding us of “The Matrix” Neo final scene, resurrected within the Matrix and capable to stop the  agents bullets and move faster than their moves. Seeing Luke being blasted with all the firepower and stood still made us feel Luke reached the uber-jedi  Rank and was appearing as the Jedi. Only to realize he was transposing himself from a distant galaxy, with the sunset on him. This final scene had some profound meaning for me because it was a direct call to my childhood heroes and it was also meaning that the sun is set on our childhood heroes. Han Solo was gone, Luke is gone and Leia is also gone.
My son loved it, but me I stood at the end of the credits sequence and thought. Maybe I am getting old, maybe I am becoming an old shmuck thats mind is stiffening overtime and incapable to show flexibility. I thought to myself that Episode IX will likely be my last one. I don’t see myself piling up another trilogy and I feel somehow sad to see that Star Wars is becoming a cash cow for Disney, milking it ad nauseam (we are not yet having Star Wars condom but I would not be surprised to have some). Maybe it is time, that as Luke, Han and Leia, I close my eyes on Star Wars.

[SciFi/Star Trek] Star Trek: Deep Space Nine (25th Anniversary)

Today marks the 25th anniversary of Star Trek: Deep Space Nine (aka DS9). It marks the branching out of the Trek Universe, five years after the launch of Star Trek: The Next Generation and was running in parallel to the latter one.
It first aired on January 3rd 1993 and in my opinion constitutes the best of the Trek Universe and follows the life of the Deep Space Nine station under the command of Benjamin Sisko. Some people claims DS9 took the idea from Babylon 5, indeed DS9 preceded Babylon 5 by a year roughly.
The series starts chronologically right by the end of TNG Season 2/beginning Season 3 “Best Of Both Worlds”  when Capt. Picard is captured by the Borg collective and became Locutus of Borg. Under his command, the Borg lead the massacre of Wolf 359. The DS9 pilot starts here in which Benjamin Sisko (played by Avery Brooks) serving on a Federation ship amongst his wife. As they try to evacuate the ship, Benjamin lost his wife from collateral damage and constrained to abandon ship in an escape pod. Back in Earth and a couple of years following the Borg encounter, Benjamin is offered the command of the Deep Space Nine station (also referred as Tevok Nor), recently recovered from the Cardassians following their retreat from the Bajor planet, ending their occupation of the planet.
For any means, getting command of the Deep Space Nine is not the most enjoyable assignment: located in the deep end of the Alpha Quadrant, near a planet that remains primitive (Bajorans lack spaceship transportations) and a highly mystical civilization (Bajorans share many similarities with Bhuddism). In order words, this station is considered as being assigned at the frontier of the Federation.
Benjamin comes in with his son Jake, in a dirty, rusty and isolated station and get command of the station under the Federation mandate. As we discover Benjamin Sisko exploring the station, we get introduced to newcomers of the Federation. We have some familiar faces in the person of Senior Chief Petty Officer Miles O’Brien (played by Colm Meaney) transferring from USS Enterprise (we have seen O’Brien in several TNG episodes) amongst his wife Keiko (played by Rosalind Chao) and their daughter Molly. We also have newcomers in the persons of Dr. Julian Bashir (played by Alexander Siddig) and Lt. Jadzia Dax (played by Terry Farrell). Bashir is this young and prodigious doctor eager to discover new horizons. For him, assigned to the frontier of the Federation is a boon and considers it as an formidable opportunity. But behind his joyful and prodigy hides an important family secret that comes in later to haunt him.
Dax is the second time we got introduced to the Trill alien race, a race that is involving a symbiont as corporal support. It is a very interesting character as Trills carry over memories of their previous hosts and often change their gender through the circumstance. Jadzia (female) is the 8th host, following the transfer from Curzon (male) Dax. Benjamin knows Curzon very well and gently refers as “old man” and keep that friendly relationship with Jadzia. It is an interesting concept by bringing the discussion of transgender and LGBT into the Trek Universe.
Amongst the members of the Federation, we also discover the “locals” of the station. We have firstly Major Kira Nerys (played by Nana Visitor), commander from the Bajorian Forces and representing Bajor in the station. We get introduced to Odo (played by Rene Auberjournois), a “changeling” alien that is a fluid-like alien capable to morph into any shape and structure. He was the Chief of Security under the Cardassian occupation and remains as is in the current station. We also get introduced to the Ferengi in more details by the presence of Quark (played by Armin Shimerman) owner of the bar. Quark hold the bar business with the help of his brother Rom (played by Max Grodenshik) and his nephew Nog (played by Aron Eisenberg). In addition to serving alcholic beverages, Quark also maintain some Dabo tables (a complicated gambling game looking like a roulette game) animated by the presence of Leeta (Chase Masterson) and by the presence of Morn  (Mark Allen Shepherd). Finally, the last but very important protagonist is Elim Garak (played by Andrew Robinson), the owner of a tailor shop. Behind his jovial and very warm character, Garak hide a heavy and dark secret that we only learn later in the series.
Early on, the discovery of a wormhole leading to a brand new uncharted Quadrant (the Gamma Quadrant), transform this remote space station as a formidable frontier hub for those traveling to this Quadrant and coming from it.
This congregation of different characters coming from different horizons and different species make this melting-pot that made the DS9 station unique. It look like a Babel tower in space, in which different cultures and aliens cross their way through. The first two seasons are sure campy and make the rides bumpy but by the end of Season 2, the magic formula slowly started to take in and take some radical different directions than the utopia set of Gene Roddenberry. DS9 shows us that the future is full of shades of grey, with characters fighting their own demons and depicting that the Federation is not as shiny as it is.
We get into very interesting story arcs: the Federation-Cardassian treaty that surely ended up the bloody war (we learnt about Miles past as a soldier) but failed to consider the impact of setting DMZs on the population (creating the splinter cell known as the Maquis, taking the name of the French Resistance during WWII). We also get introduced to the Bajoran-Cardassian relationship and the relationship between an occupier belligerant and the occupied, shattering through the idyll of the David versus Goliath. Both camps shed blood and blind terrorism in the name of a cause. But also both camps knew to fell in love (thats really speak to me, as I see it as a metaphor of the occupation of France by German Nazis, with the French population). We also get introduced to the Dominion, a metaphor of the Pax Romana that offers you peace with the condition that you surrender your authority to the Roman Empire) and his army of the Jem’Hadar. An army genetically conceived with one mission: “Born to kill” and maintained in check by the use of a drug referred as Ketracel White (we can see similarities with soldiers given wine and liquors before giving the charge). I also see the Jem’Hadar as a metaphor for the child soldiers that were actively involved in various civil wars in Africa.
Things really starts to kick in when Worf (played by Michael Dorn) join the series by Season 4 (right after Star Trek: First Contact) and when Sisko takes on the “Samuel L. Jackson” goatee look. This exponentially increased the awesomeness of the show by deeply exploring the whole Klingon folklore superficially explored in TNG.
In addition to the story arcs, we have important topics discussed through different two-series episodes with some of the best Star Trek episodes ever created in the whole Trekverse. Look at the “In the Pale Moonlight”, “Assault on AR-558” and many others.
If you have not seen DS9, you have been missing big time. I would however recommend to skip some episodes in Season 1 and 2, especially those that are not associated with the main story line (Bajor or Maquis).

[Metal] Happy Holidays! My 15 metal albums and EPs of 2017!

Happy Holidays everyone! As we are now engaged in the last week of 2017, it is a great time for me to go back through my library and pick my 12 albums of 2017. No particular rankings, most of the albums have been reviewed in my blog. I have set the EPs aside since they are not counted as album.

1. January: Xandria – Theater of Dimension

2017 started with a bang with Xandria releasing their latest album and the second album with Dianne Von Giersbergen as front vocals. The motto was “harder, faster, stronger, better”. Damn it was a good album to listen, Dianne being perfect as usual. Unfortunately, the rest of the year was less good for the band. The second leg of the US tour cancelled, Dianne thrown in the residue bin like an used ragdoll. Fortunately, that also means that Dianne is likely reviving Ex-Libris.

2. January: Au Champ Des Morts – Dans La Joie

It is not often that you find French metal bands getting under the spotlight (unless you are Gojira or Alcest), even less French metal bands that sing in French. This was a pure random encounter in my discography, during a Bandcamp campaign (damn Bandcamp is such a great place to discover bands). Mixing elements of black metal and doom, it is a delight to listen to the French lyrics. A must-have in your collection if you are also attracted to the dark side of the Force and needing to find a solace to old wounds.

3. February: FT-17 – Marcellin S’en Va En Guerre

Another Bandcamp pick. Aside from sciences, metal, Sci-Fi and video games, I have another great interest. History! In particular, I am very fixated on World War I: “la Der Des Ders”; “La Grande Guerre”; “La Guerre Des Poilus”. Don’t ask me how my brain clicked on that particular war, maybe because of that field trip during my middle school year at “Le Col Du Linge”, harboring trenches and a museum of this horrible war. The context of military history is not much new and those who know Sabaton know their power-metal hits narrating historical battles. This one is particular. This first album of the melodic death metal band FT-17 (named after one of the first type of French assault tank “Renault FT-17”) is particular as it follow the PFC Marcellin Trouve, writing to his notes his experience of the war, from the joyful draft and heading to the front line to the delusion of the war.

4. March: Midnight Sorrow – Pick A Tale

March was highlighted from the release of the first album by Midnight Sorrow, another French band but this time from my hometown and in the Symphonic Metal genre. I really liked their first EP “At First” and this album took some time to come in, but it was indeed for the better. Coming from their EP, you can hear the maturation of the band in both the musical arrangement (bolder, more confident) and also from Maureen’s voice (in which you can really hear her progress on her vocal abilities). I usually hate when the album is recycling old songs from the previous EP but the band went the extra mile and revisited their songs giving them a second breath with their more experienced sound. It was such a delight to hear that album.
https://youtu.be/syiCMalo44Q

5. May: Seven Kingdoms – Decennium

One thing that I found a bit boring on the US metal scene is the vast domination of the death metal scene and its derived genres (metalcore, deathcore, grindcore…). For some reasons, European favorite genres like Power, Symphonic or Doom are not that popular. So when you have a US metal band playing outside this “terra cognita” it is a welcome. When that same group slap you with a damn awesome album, it is even more welcome.
Hail to Seven Kingdoms, straight out of the Florida panhandle. Florida has a reputation of being the weirdos in the US but they are also home for two awesome US power metal bands: Kamelot and Seven Kingdoms. 72 minutes of a powerful joyride into the meadows of an enchanted land, riding over a robot unicorn, riding in the sunset of a binary star system, slashing an horde of orcs running over using your proton axe to slay the foolish and the foes. If Warhammer 40K should have a soundtrack, I would definitively pick Seven Kingdoms. Just listen to “Stargazer” and tell me you are not all pumped up.

6. May: Alwaid – The Machine & The Beast

Alwaid is another French Metal band that highlighted my album picks in 2017. This second album was quite a departure of their first album “Lacus Somnorium”, that was deeply anchored in atomspheric doom metal. This second is much louder, faster and heavier, more anchored into melodic death but yet with keeping their signature melodics. Again a very good pick and an extensive review of the album on my blog site.

7. June: Neverlight – Nova Red

Neverlight (from Colorado) is this kind of UFOs in my library, standing out by their inability to put them in my classical shelves. Labelled themselves as “dark progressive metal”. It offers a very unique prog metal songs, sharing some similarities with Amaranthe (if you are heavy in the keyboards) but yet very different as it has more darker tones and lyrics. You know what? Enough with the talk. A damn good prog metal album in my library and it pays off to wander into “terra incognito”, just give a try.

8. August: Seven Spires – Solveig

This was another pleasant surprise, as this band straight out of Boston (MA) came out from nowhere and got me hooked up with their title “The Paradox”, directly inspired by Dimmu Borgir and Cradle of Filth. The album per se was very good: engaging melodics, pumping you up with energy and willing you to summon a mosh pit in your cubicle. Playing in different registers, surfing from gothic metal songs like “The Siren/Encounter” to something more mainstream like “The Cabaret of Dreams” to some melodic power metal songs like “Choices” or “Distant Lights”. My favorites remains though “The Paradox” and “Burn”. I leave you with the Paradox official video so can make your choice.

9. September: Paradise Lost – Medusa

Having one of the Unholy Trinity bands release a new album is always welcomed. Paradise Lost “Medusa” is one of these welcome. Adopting a “back to the roots” in terms of the artistic direction of the album, splurging into death doom made this album very special and a hit amongst critiques. It got a very good review on my blog, you can find it.

10. September: Arch Enemy – Will To Power

After 3 years of waiting since “War Eternal”, Michael Amott finally broke the silence and brought on “Will To Power” right to celebrate the 20 years of the band. It was also the second album featuring Alissa White-Gluz. So it was a litmus test for many of the fans and the result was far from disappointing, also a long awaited moment since Jeff Loomis joined the band. It was a hit at first sight with in my opinion a better writing than “War Eternal”. It is brutal (with even some punk influence in the melodics) right from the first track “The Race”, followed by “The World Is Yours” flying into epic melodic power ballads with “The Eagle Flies Alone”. Following the release, the band started the US tour. It was magic! The best concert of 2017.

11. September: Septicflesh – Codex Omega

Septicflesh is a unique band mastering the blending of a classical orchestra with the black symphonic metal style giving you an auditory experience of some of the paintings of Bosch, very finely crafted orchestral arrangement, navigating the different layers of Hell through “Dante’s Inferno”. With Septicflesh, you are welcomed into the Hades Kingdom, navigating through the Styx with Spiro being your guide. A must have if you are attracted by the Dark Side. Considering Spiros and the band are coming nearby for a gig in March, I guess I will add it in the bucket list.

12. September: Clouds – Destin

Whatever I listen, I always come back to doom metal. Behind the darkness and the melancholic tones, I find solace and relief to my mind. There are words I cannot speak, there are feelings I cannot tell, there are wounds that I cannot heal. Doom metal provide me with this opportunity of a catharsis. In sorrow, i found my relief.
This is the case of Clouds “Destin”. Nicely composed, it helps open myself to my mind, let all my sadness, my pain and my sorrow exhale and breath. It allows a deep introspection that few releases can help me cope with these feelings. If you like doom, you MUST try this band.

13. October: Hallatar – No Stars Upon The Bridge

Hallatar is a side project involving various Finnish metal band members including Tomi Joutsen (Amorphis) at the vocals, Juha Raivio (Swallow The Sun) at the guitars and Gas Lipstick (ex-HIM) at the drums. This album is one of the best doom album of the year for different reasons.
Firstly, it is a an album dedicated to the memory of late Aleah Starbridge that left us orphan last year. Secondly, it is an requiem and eulogy album to Aleah, using her poems, giving us a last intimate moment to mourn. The result is simply fantastic and heavy loaded in pain and sorrow. I just hope that this album is closing our mourning on Aleah’s passing and not become an opportunity for anyone to make financial gains on her.

14. November: Evanescence – Synthesis

After a hiatus of over 5 years in terms of album, Amy Lee released “Synthesis” last November. It is per se not a new album, rather it is a an album providing a reorchestration of selected songs spanning through the previous three albums of the band. Some of the songs sound as good as the originals (e.g. “Lithium”), some are even better than original (e.g. “Never Go Back”) and some simply bomb the original (“Bring Me To Life”). It remembers how great Amy is on the vocals and on the piano, and really make us think if Amy decided to “Europeanize” her musical style by taking the best of Symphonic metal.

15. November: Beyond Forgiveness – The Great Wall

“The Great Wall” is the first full-album from the US gothic/symphonic metal band Beyond  Forgiveness (Colorado Springs, CO). I reviewed the album extensively earlier in November so I will comment that much.


The EPs and other albums that were good:
Aside from full-albums listed, there was also the release of “In This Moment We are Free – Cities” by VUUR. With Anneke Von Giersbergen fronting it, it was a great moment to listen in something much heavier than her band “A Gentle Storm”. The album was good, maybe too simple and reminded me a bit the good old times when she was with The Gathering. Maybe a bit too simplistic.
Epica also released an EP “The Solace System” that is a continuation from the “The Holographic Principle”. Again, it was awesome as usual from Epica. You can find more about in one of my previous blog posts.
Another interesting EP I got my hand to was “The Ascension” from Casket Robbery (Madison, WI) formed by Cory Scheider. You may not know Cory but if I am telling you that Cory was part of Luna Mortis, then it will all make sense. Cory put a bit away the melodic death tunes from Luna Mortis and brings in more the brutality into the melodic death. With Megan Orvold bringing the brutal vocals in the line of Angela Gussow (ex-Arch Enemy), you will wish to open a pit of hell inside your living room.

Finally, this year I also got introduced to sludge metal by attending a gig featuring two bands: Rozamov (Boston, MA) and The Ditch & The Delta (Salt Lake City, UT). If you are unfamiliar with sludge metal, it is a blend of doom metal with some Southern death and punk. It has this roughness and Southern flavor that my current doom library is missing. It worth the try. Here two videos are listed from the two bands: Rozamov – “Serpent Cult” and The Ditch & The Delta – “F*ck on Asphalt”

[Stroke/Junk Sciences] Does a needle can save you from a stroke injury? No! No! No!

Some of you have seen this video going around, claiming you can save someone suffering from stroke injury using a needle. The idea behind this video, according to HealthyChoices365, is that a Chinese “professor” claimed this will save the person’s life following a stroke.
This is kind of the thing that, as a basic scientist in the field, boils me for the last few days. First, it is plain quackery. The needle prick has nothing to do with the stroke event: it is distal from the site to have an effect. Second, using this technique on a patient has a direct impact on the patient’s stroke outcome and recovery. Let me explain why this is bullshit and should be called for what it is: A gazillion pile of bullshit that has much more weight that all the coal West Virginia has and had since the geological formation of that region (no pun intended, W. Va has one of the highest number of stroke per capita in the US, since it is Xmas season the lump of coal is simply appropriate).
In brief, stroke is the 5th cause of death in the US (3rd amongst women) and a leading cause of disability. We have two types of stroke: ischemic (85%) and hemorrhagic (15%) with the later accounting for 40% of stroke-related deaths. We estimate that about one US citizen will experience a stroke event every 5 minutes.

1. Stroke 101: Back to basics
In the ischemic stroke, we have a clot (usually formed at the carotid artery bifurcation) that is formed due to the presence of atherosclerotic plaques. These plaques can become unstable and crumble over time. These crumbles are made of clot that navigate through the carotid artery that irrigate the brain. Such clot will act as a plug or a cap, once it reaches a vessel with a diameter smaller than the clot, it will occlude it and block the blood flow.
This create what we call an ischemic situation. In such ischemic situation, the brain is deprived of both oxygen (20% of all oxygen is wired to the brain) and nutrient (in particular, glucose. The brain accounts for about 25% of the total glucose level utilization in the whole body). Neurons are the most sensible brain cells to stroke injury. They cannot adapt to hypoxia (lack of oxygen). Few minutes of hypoxia is enough to cause severe and irreversible brain damage. We estimate about 1 million neurons die every minutes that a stroke is left untreated.
Furthermore, neurons are post-mitotic cells. They cannot divide anymore. When a neuron is gone, it is gone, as well as its neuronal circuitry. You see, each minute matters because what is lost is lost.
Stroke signs can be resumed by the “FAST” acronym: Face droop, Arm weakness, Speech issues, Time to call 911. By the time you are showing signs, it has been already a couple of hours your brain has been starving off glucose and oxygen. It is important that once you have the signs to call 911 and asked the paramedics to direct you to the closest stroke center.
The most important thing to happen in stroke diagnosis is to determine which type of stroke the patient is undergoing: ischemic or hemorrhagic? These two are very different and confusing one with another can have a deadly effect. You don’t want to give a clot-buster to someone with hemorrhagic stroke because it will make the bleeding worse. You don’t want to give a clotting agent to a patient with ischemic stroke because you will increase the risk to develop a second stroke.
The current procedure is the use of endovascular intervention: the neurosurgeon insert a catheter in the femoral artery and using an angiography method to see blood vessels “live on screen” reach the site of stroke injury to either remove the clot or to put a stent in place to stop the bleeding process. From discussing with a physician, this takes about 10-15 minutes once the patient is in the OR.

2. Why this video is BS and should be called BS:
Now, lets see why I call this video BS.
First, the idea of finger prick to treat stroke is BS. We are trying to act on the stroke from a remote site. The thing is, the clotting process occurs in a very local fashion. So trying to act on a stroke with pricking a finger with a needle is mostly useless.
Second, as I said, it is important to know which type of stroke we are treating. You cannot identify which type of stroke is involved just by the clinical signs. You need imaging (CT scan or MRI) to be able to distinguish ischemic stroke from hemorrhagic stroke.
Third, this useless procedure is a formidable waste of time on the patient. As we said, each minute lost is a precious minute lost that will condition the outcome and the recovery. How long should we waste before calling 911 because we noted no improvement: 15 minutes? 30 minutes? 60 minutes? By the time the patient realized this intervention is bogus, his/her chance to survive and recover from the stroke injury are almost close to zero.

To conclude, let me finish this post with a call: PLEASE! PLEASE! PLEASE! Whenever you or a loved one is showing the FAST signs, CALL 9-1-1!!!! Know your nearest hospital with a certified Stroke Center and have the paramedics bring you there. THERE IS NO THERAPY FOR STROKE! OUR BEST BETS ARE PREVENTION (80% of stroke events can be prevented) AND INTERVENTION (by keeping the “door-to-bed” to a minimum).