About Me

My name is Abraham but everybody calls me “Abe”. I am a biologist by heart and neurovascular biologist by mind. I blog everything about that I consider an interest to share and I want to give my opinion on sciences, science-fiction/horror, videogames and so on….

Please feel free to share my news and dont hesitate to leave any comments.

Thank you 🙂

Abe.

23 replies on “About Me”

Hi Abe,
My 15 mo nephew has been recently diagnosed in Rotterdam with Allan-Herndon-Dudley syndrome. To say that we’re completely smitten and have no idea where to turn to is an understatement. You’re mentioning working with Svendsen Lab at Cedar-Sinai. Is the research on AHDS still going on? Any success & breakthroughs? I mean, I read the paper about zebrafish, don’t know, I’m an accountant by trade so for me it doesn’t seem to be of much help to my nephew… Is there any other lab or center in the whole world involved in the research for AHDS?
There are some clinics in Lebanon, Germany & China that list AHDS among the conditions treatable via stem cells treatment. In your honest expertise, how viable is their claim? Thanks a lot!
Best regards,
Laura

PS
I’m totally with you on “Elan”!! 🙂

Liked by 1 person

Hi! I’m so sorry, I’ll bug you again with my AHDS story. You’ve been super helpful and straightforward when you answered my first post and no good deed is left unpunished :)!

We’re still waiting for the ok for joining the Rotterdam Triac trial, nothing to do with people over there but more with local handling of the issue ( my nephew lives in Greece but the trial will be deployed to Bucharest so happy-happy-joy-joy in Balkans style ). This is not a total loss of time because my sister had some time to adjust to the idea and to do lots, but I mean lots of research on the net and to get in touch with various specialists including nutrition, endocrinology physiotherapy and so on.
We also got in touch with people who are administering Triac to their kids either inside or outside the trial and the feedback was quite mixed in terms of opinions some of them claiming that there is no improvement whatsoever in their kids status. I mean I know it is not a miracle drug but I was at least expected a more positive outcome.
So now to the question. Is it possible that in fact the way of being given to the kids ( oral ingestion ) may account for the reason for the lack of improvement in their condition because lot of the active ingredient is lost along the way before even reaching the BBB?
The reason I’m asking is because of these links/studies:
http://www.ncbi.nlm.nih.gov/pubmed/25801717?report=abstract
http://vivirsindolorelsalvador.com/en/procedimientos/bombas-intratecales-de-opiodes/
Would either of this 2 means of getting the hormones inside the body be a doable endeavor in the case of the “artificial” hormones in Triac in order to get them quicker to BBB instead of ingesting them? And if yes, what would it take and be needed to develop such procedures?

Thanks a lot, really:) !!
Regards,
Laura

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Hi Laura,
Thank you for your message. First of all, I am glad you were able to get your nephew into a clinical trial and what I can say now is to cross my fingers that it works. Entering clinical trials is like entering a dark maze: we know where we came from, we know that should be an exit somewhere but there are plenty of dead-ends that can get us stuck and have to move backwards.
I have moved away from the AHDS field as I had to focus my research interests in my lab (I am focusing on stroke research and other neurological diseases with a genetic defect at the BBB) but I remember some groups working on developing a synthetic version of the thyroid hormone that can bypass the defective MCT8 and enter the BBB. There are different ways you can bypass the BBB and the intranasal has been a new venue for delivering peptides and bigger cargo inside the brain, some results are fairly optimistic. There are others that try to use vectors to deliver contents across the BBB and finally there is still one method thats works but also the most invasive and the most risky: the intraventricular injection.
TRIAC is the synthetic one (avoiding the MCT8) and the early clinical trial will tell us how much cross the BBB (based on much is injected) and adjust the dosing. Again, safety is first and a direct injection can be devastating and lethal. By increasing the dose, we may have some entering the BBB and accessing the brain.
Finally the hardest part is the randomized double-blind studies. There are two groups: one receiving the placebo (a sugar pill) and one receiving the sugar pill with the TRIAC. But neither the patient or the doctor knows who is on what. This is frustrating but also very important because we can have an objective conclusion rather that having a confirmation bias and see improvement because we want to see it whereas there is not.
At this point, I can just say good luck, wait and see. Clinical trials are like tortuous dark maze. We came from a bright entrance and know there is an exit somewhere. But there are plenty of dead-end corridors and we may spend a lot time getting stuck there.
Good luck!

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Hi Jamie-Lee, it was a pleasure to list your band. I had this in the making for a while and thought July 14th would be a great day to promote metal bands from the “francophonie”. i know it is an amateur blog but I believe there is nothing small and good bands should be promoted. Good luck with your tour 🙂

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Hi Abe! 🙂 I’m Kirsten, singer of Evig Natt (Eternal Night) and I was wondering if you’d be interested in checking out our latest release? Maybe give us a shout on your blog? If so, let me know what e-mail I can use to send you a promo kit! Hope to hear from you! Kind regards Kx

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Hello Abe:

It was recommended to me that I contact you regarding Mercy Isle and our recently released album “Undying Fire.”

The album was released on 21.October.2016, coinciding with Metal Female Voices Fest XIII in Belgium and our performance there on 23.October.

Would you at all be interested in downloading our EPK and mp3 album? If so please feel free to email me at mercyisle@gmail.com.

Contact name: Kassandra Novell
Band name: Mercy Isle
Country/location: USA-Netherlands
Album name: Undying Fire
Release date: 21.October.2016
Label: unsigned
Genre: Rock/Symphonic Metal
Similar artists: Trillium, Delain
Preview site/website: http://www.mercyisle.com
Related video link (album trailer): https://www.youtube.com/watch?v=DSbGIf5kY4M

Sincerely,

Kassandra Novell
Mercy Isle (Vocalist)

E-mail: mercyisle@gmail.com

Website: http://www.mercyisle.com

Social media:
https://mercyisle.bandcamp.com/

https://www.facebook.com/MercyIsle/

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Hello Abe, how are you?
My name is Drake Chrisdensen, I am the Tenor of the Epic Symphonic Metal band Ruins of Elysium (www.facebook.com/RuinsOfElysium).
We will release our new album Seeds Of Chaos And Serenity on April 4th and I would like to know if you would be available to listen and review it. I’ve seen your review of Mercy Isle’s Undying Fire and I really liked it. Please, send me an email at ruinsofelysiumofficial@gmail.com and I will forward you links to download the full album.
Here is the link to the lyric video of Serpentarius, first single from Seeds Of Chaos And Serenity: https://www.youtube.com/watch?v=9vyvPkz9cLo

About the band:

Name: Ruins of Elysium
Location: Brazil/Italy
Album name: Seeds Of Chaos And Serenity
Release date: 4.April.2017
Label: unsigned
Genre: Epic Symphonic/Power Metal
Similar artists: Versailles, Rhapsody of Fire, Xandria
Social Media links:
http://www.facebook.com/RuinsOfElysium
http://www.reverbnation.com/ruinsofelysium
ruinsofelysium.bandcamp.com
http://www.instagram.com/RuinsOfElysium
twitter.com/RuinsOfElysium

Thank you so much for your time.

All the best,
Drake

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I found your comments about aluminium and the BBB with the connection of vaccines. You seem to debunk the theory that aluminium can cross the BBB and also appear to state that AZT also does not cross the BBB…unless I have misunderstood. I disagree with both of those opinions and have seen an abundance of scientific evidence that both have been shown to pass the BBB.

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Hi J. Thanks for your comment. Well what I can say are there are some inconstancies in your claims in regards of what you mention and what is on my blogs. So to not get into an argument, I propose we sort it out, by referring back to the main post I have on Al in vaccines.
1. “You seem to debunk the theory that aluminium can cross the BBB”. I certainly not said that, such claims came from the VP post that was claiming Al was entering the brain via macrophages. My answer to that claim was the following “A critic I have with his statement is how the author can exclude that Al3+ cannot cross the blood-brain barrier (BBB)? I will talk about the BBB later but I wanted to mention this logical fallacy. We just discussed about the neurotoxic effects of aluminum in the CNS, using Al(Cl)3.”. I mentioned the case of toxicological studies assessing the neurotoxicity of Al via ingestion of AlCl3. Remember, this is AlCl3 not Al(OH)3. We cannot compare oranges to apples but we can compare to the endpoint that is free Al circulating in plasma.
2. “and also appear to state that AZT also does not cross the BBB…unless I have misunderstood” AZT? Never mentioned of AZT. If you are mentioning AZT for azidothymidine, then yes there are some studies outside highlighting the low permeability of this drug at the BBB. It seems it is not exclusive to this antiviral drug but other kind as well (ritonavir comes in my mind). I would argue the reason of such poor permeability maybe due to their interactions with efflux pumps such as P-gp or BCRP at the BBB. If you are interested, you can look at this study on AZT below.
https://www.ncbi.nlm.nih.gov/pubmed/9593963
3. I thought it was clear in my blog post and if it is not I will make it clear here. Al cross the BBB (probably via the DMT carrier, that is involved in bivalent cation metals). What matters is how much is in the blood plasma. As I said in my blog post, Al neurotoxicity is to be considered when you have constant IV infusion (during total parenteral nutrition) with Al-containing IV bags, especially when you have immature kidneys or have a serious kidney condition. The FDA set the miminum toxic dose to 5mg/kg/day.
For AZT, since I have not mentioned anything I cannot rebuke anything. I would say that my current understanding is antiviral drugs have probably a low penetration across the BBB but this would require some literature search that I would be happy to help on.
Thanks.

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I just want to respectfully say that you aren’t very well informed on the subject. Maybe you should do some research before making such difinative statements about essential oils. I trust nih and the research that exists a lot more than your so-called expert opinion. Herbs and essential oils have been used medicinally dating back to Bible times as well as ancient civilizations. In fact it used to be the only medicine we had before scientists and synthetic medications became available. We don’t need science to tell us that lavender essential oil immediately takes the sting out of bug bites or that tea tree oil helps acne and scalp issues. Or that eucalyptus can make respiratory issues feel better. Please do some research maybe you will have a different opinion. You are scaring people away from something that some of them can benefit from. All due respect intended.

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Hmmmm…you know telling that to a pharmacologist that has done his master thesis on polyphenols and their biological activity is the least to say interesting. You made some good points but also still a lot of mistakes.
1. You claim essential oils have been used back in the Bible times. Where to do you put that? On the Ancient Testament? Lets be conservative, lets say 5000 B.C.? I may argue that maybe EOs are even older than that and maybe as old as mankind and the first hominids. What we call pharmacy today is what what we used to call shamanism and sorcery as mankind learnt to interact with his/her environment. I guess a lot of error and trials (with fatalities) led us to develop what we call today the Pharmacopea. We are still discovering new molecules from fungi and recently marine products. But it is still a hell of chemical synthesis to produce natural compounds as simple as morphine (that is looking fairly simple in terms of structures, there are some very exotic structures out there that make you enjoy if you like organic chemistry).
2. Indeed we need science to tell us which compound out of the secondary metabolism harbor the anti-inflammatory and analgesic properties. This is done via an old discipline of pharmacy called pharmacognosy and despite not being taught anymore is very useful to link plant biology and pharmacology. As you can see it in this reference, we dont have one but over 40 compounds present in lavender EO (https://www.academicjournals.org/article/article1380119091_Hui%2520et%2520al.pdf). Some of them will soothe, some of them may indeed aggravate the symptoms. This is why it is important to know their composition and their pharmacological activity alone or in combination.
3. Eucalyptol is a very interesting molecule, in particular with its odd epoxy group. At small dose and applied in a nebulizer, it will act as a mucolytic making you breath better (think about Vicks VapoRub, the classic OTC stuff you buy in winter). But if you apply too much or provide it in the wrong route, you can die from CNS depression (that will shut down your brain respiratory centers and die from asphyxia. This is probably why it is not indicated for children lesser than 2 years).
(source: https://toxnet.nlm.nih.gov/cgi-bin/sis/search/a?dbs+hsdb:@term+@DOCNO+991).
Yep, Mother Nature is a very talented chemist with probably the largest chemical library we will have ever access to mankind. But it does not mean that everything is good, some are very harmful and even fatal. As Paracelsus said: “Everything is poison, nothing is not poison. The dose and only the dose makes it the poison”.

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Hello Abe, found your review of Exley’s autism / aluminum paper / experiments and found it very well done. I would love to point the less sound minded to your review. Unfortunately, I can already hear their reply “what are THIS GUY’s qualifications that we should believe him (though your comments were very pointed with regard to *anyone* doing any kind of research/study and the publication regarding finding). I can understand wishing to perhaps keep possible identifying details of your life private given the vindictive and unrelenting nature of internet trolls. That said, would you be able to share a bit more of your credentials? (Ex: “I hold a PhD in nuclear basket weaving and have been conducting experiments and research into the effects of such on marmosets for the last 30 years…”) Thank you very much for considering my request and thank you for your voice of reason sounding out against the barbaric yap of those with an agenda.

Liked by 1 person

Hi Kelly, thank you for your answer.
Wel, what I can say? I have a BS in Biochemistry and a MS in Pharmacology from France, I have a PhD in Human Physiology and Neuroscience from Switzerland (this month marks my 10th anniversary of my thesis defense of designing a blood-brain barrier in vitro using a 2-D and 3-D cell culture), I have five years as a postdoc in the US in two Tier 1 University ranked in the Top 100 list (Shangai Ranking). I am a tenure-track assistant professor in a School of Pharmacy in Texas. I teach pharmacokinetics and pharmacogenomics to PharmD students, advanced neurosciences to PhD students. I have over 25 peer-reviewed studies out there as a BBB expert, including 6 as a senior author paper. My research focuses on modeling neurological diseases in a dish using induced pluripotent stem cells (iPSCs) with a particular interest in stroke research, Alzheimer’s and GLUT1 deficiency syndrome.
If you can identify me with these information, then you can easily track my publication record in Pubmed and assess my record as a peer-reviewer for several journals in Publons.
Sure, Exley is a higher rank when it comes to publication record and academic status, however publishing papers that lack controls, use poor methodology (the morin staining and the subsequent immunofluorescence pictures quality makes the guy that I am enjoying spending hours in the microscope room screaming) would make any graduate student jump in a journal club. Having your belief overcomes the scientific rigor and critical thinking as a scientist, bend the data because they dont fit your narrative or your benefactors agenda (Exley is both sitting in the CMSRI scientific board and getting research fund from them) is very dangerous and violates what you have been taught by your mentors as a grad student and a postdoc.
If I could have funds to assess Al toxicity at the BBB, I would be more than happy to do that.

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Hi Abe,
I am working with the number of professionals to counter vaccine refusal hesitancy etcetera, in the Orthodox Jewish community where we currently have a tiny measles problem…
Someone just posted your excellent piece on aluminum to our WhatsApp group.
I am looking for straightforward information on the safety and metabolism of aluminum.
Any reliable information not behind a paywall be greatly appreciated.
Thanks so much,
Alisa

Liked by 1 person

Hi Alisa, thank you for your message. If you have read the blog post I have, then you have about most of it here, so it hard to add really extra information unless you have really specific questions.
For the safety, I would definitely point the fact that aluminum as adjuvants started to used in the 1930s, but really the first study that I found was really looking at efficacy and safety is a very old paper by Bell and colleagues published in JAMA in 1948 (you should have free access to it: https://jamanetwork.com/journals/jama/fullarticle/300794).
In this one, they used a DT vaccine and compared the efficacy (and accessory the safety) by treating the same batch into two groups: one group was mixed with aluminum adjuvant, the other left as is. One was given to newborns and infants born in odd months (mixed), the other was given to those born in even months (unmixed). The authors followed these two groups for 2 years and reported no adverse effects or developmental delays. Those that received the adjuvant had a more efficacious response than those without.
For the metabolism of aluminum, there is not such. Aluminum adjuvants are salts that dissolve in aqueous solutions into free aluminum ions Al3+. These Al3+ ions reach the systemic circulation and end up eliminated mostly (95%) via renal clearance. There is a very good review about by Robert Yokel on aluminum pharmacokinetics (Yokel and McNamara, Pharmacol Toxicol 2001) but it is behind paywall (you can try Sci-Hub to get access to it).
There is also two studies that looked at peak levels in aluminum recently: a study by Karwowski and colleagues that measured Al levels in blood and hair from infants and toddlers and found no correlation between Al levels and immunization status.
The other study from Weisser using Al-citrate (a very fast dissolving form of Al salt) showed no difference in Al levels in blood and brains in animals treated with doses equivalent to a shot.
So I can say that we have been using it for almost 100 years, and that millions of children received aluminum-containing vaccines during that period without any signs of developmental delays. If aluminum adjuvants were a concern, then you would expect to have robust studies showing the presence of an issue. But ask for these papers and you will find a list of papers with severely flawed designs and methods, if not with manipulated data in them. Several of them got retracted because of blatant fraud, or experimental designed so poorly it should not have been passing through the peer-review filter.
https://www.sciencedirect.com/science/article/pii/S1876285917304837?via%3Dihub
https://dx.doi.org/10.1007/s00204-018-2323-8

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Hello Abe,

I am currently trying to determine on whether a should continue vaccinations with my first child and start vaccinations on my second child. I am starting from the view point that vaccinations are not harmful. However, a personal experience with a family member along with a number of anit-vaccination information has been making me hesitate and second guess myself. My problem is that I find information on both sides to be largely accusatory with little facts to back up their opinion (for example, pro-vaccinators call anti-vaccinators “monsters” and “stupid” and anti-vacicnators call pro-vaccinators “brain washed” and supporters of Big Pharma). I rarely see a debate between two individuals that are knowledgeable on the subject that challenge each other in a respectful way that promotes education and knowledge on the subject. Every article comes across bias and most scientific information is hard to read and might as well be written in a different language for someone like me.

I have recently reviewed videos/articles written by Dr. Judy Mikovits and Dr. Lawrence Palevsky.

Dr. Mikovits claims that she discovered that vaccines cause cancer, autism and other autoimmune deficiencies (or at least that there is a link between the two). She claims to have been silenced by the American Government and Dr. Fauci. She also pays some lip-service to the fact that while some vaccines may work, they have side effects; and that we went from giving 5-10 vaccines in the 1980’s to 60-80 vaccines in since 2015.

Can it be that some vaccines may be worth taking (i.e. polio vaccine) but some other vaccines are not worth the risk (i.e. chicken pox vaccine). And if that is true, why aren’t we given more information as to how or why these vaccines can cause side effects. I keep hearing that there is no evidence to support that vaccines cause autism. But where is the evidence to support that it does not cause autism?

Dr. Palevsky states that vaccines are put together like drugs. He describes that nanoparticles are bound to drugs so that they can pass the blood-brain barrier membrane (“BBB”). He states that therefore, if nanoparticles are bound to vaccines, it is simply logic that it is at least possible that the vaccines containing mercury, formaldehyde, aluminum etc are able to reach the brain through the BBB. He also states that there has been no research to determine whether these vaccines are getting though the BBB and getting into the brain. He further states that if they did get into the brain we would expect these ingredients to cause inflammation to the brain. He then goes on to say that children with autism, behavioral problems, learning disabilities etc have inflammation in their brain. Concluding that without evidence supporting that vaccines are not doing this, we should be careful with what we are injecting our children with.

I have no idea if the above is true. All I know is that I cannot find anything that categorically proves or disproves either point. I should point out that I do have a family member whose son became immediately ill hours after receiving his MMR vaccine – he was later diagnosed with autism. Based on this experience, I do not blame his parents for at least questioning whether the vaccine caused their son’s autism. He was perfectly fine before his vaccine …. I was actually with him the night before he went in for the vaccine. Did the MMR vaccine cause autism? was he just unlucky? Why are there billions of dollars that have been paid out in vaccination law-suits if vaccines are completely safe? Also, why are some children exempt from vaccines if vaccines are not harmful?

I am so confused and just wanted to be pointed in the right direction re: articles, medical journals to read etc. I read your blog about aluminum and understand your point that it dissolves within the body and that the amount of aluminum is far to low to cause any harm to the body etc. But what about the other points I reference here (particularly about mercury, the MMR vaccine and the nanoparticle that vaccines are bound with)?

Don’t worry about overwhelming me… list as many links to articles or videos that you know of. I want to read everything.

Thank you!

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Hi Mark, thank you for your comment and apologizes for that late response. COVID19 profoundly affected my professional and personal life with a lot of adjustments and extra effort that required me to refocus my priorities.
I completely understand how things can sound scary and how some “whistleblowing doctors” can make someone on the fence about vaccines being attracted to them, and even find some alignment to them.
I have to say there is a lot to unpack here but I will do my best to summarize before we break it down together and discuss on one of them at the granularity that you want.
1. About Mikovits. Oh boy, thats a long story that I have already got news about a decade ago following her retracted paper. What is interesting is that her recent stint opened a can of worms that I barely had an idea about. I knew about her Science retracted paper because nobody including herself could reproduce her findings. But as I dug through, the story became even more bizarre. Retractionwatch has been following her bizarre storyline for almost a decade and summarized it into an article.
I have to say, a “virologist” (this is what she claims to be) claiming out and loud on her “documentary” that there are no vaccines against RNA viruses on the CDC schedule and ignoring that 50% of the vaccines on the schedule are against RNA viruses (polio, MMR and rotavirus) is a big red flag that something does not click.
https://retractionwatch.com/2020/05/06/who-is-judy-mikovits/
2. I am very curious which drugs and which nanoparticles Dr. Palevsky refer to, because I can tell that would be known by now. Because so far, we have less than 5% of the drugs able to cross the BBB and virtually none of the biologics (proteins, antibodies…) can cross it (I usually cite the paper by William Pardridge, NeuroRX 2005). Drug delivery across the BBB is a huge problem with a lot of my peers struggling to find a suitable “Trojan horse” for it. Imagine if we could deliver drugs as easily with nanoparticles. That would eradicate horrible diseases like diffuse intrapontine glioma (a fatal form of pediatric brain cancer) or glioblastoma multiform (a fatal form of adult brain cancer).
3. About the MMR and autism. It was a valid question to be asked and we have over 20 years of epidemiological data out there. If there was some association, it would be found by now. With the amount of data out there, it is safe to say that there is no correlation between MMR and autism.
4. About the safety of vaccines. Vaccines are extremely safe, but there is still a slight chance of having adverse reactions (we estimate it 1 in a million). Because it is a very rare event, it is very hard to study and identify risk factors inherent to it. This is a common tactic used by the anti: the Nirvana fallacy. Because you cannot guarantee 100% efficacy or 100% safety of X, hence X must be banned or X must be dismissed. Achieving a 100% of something in life is an impossible parameter to achieve. It is like asking where is the limit of infinity.
One example I can cite is Stevens-Johnson syndrome. It is a very rare (about 20’000 cases yearly) adverse reaction occurring in patients taking certain medications such as carbamazepine (an anti-epileptic drug). It is a severe immunological reaction requiring immediate medical assistance and cessation of treatment. We did not ban or stop giving carbamazepine to epileptic patients because of the few cases, and we cannot identify a patient that will have such reaction triggered (although we have some pharmacogenomics data that identify certain population at risk). Everything in life is about risk. Any medical procedure has a risk, as small as it is it. And we have to accept this can happen and weight the risk/benefits of it.
However, patients have the right to get indemnity from medical malpractice and the Vaccine Injury Court Program (VICP) was born from the deluge of tort lawsuits in the 1980s against vaccine manufacturers. You can imagine that to avoid lawsuits, better just stop producing vaccines. But this would come at great public health cost. Hence this program allows compensation for families in which an adverse event was associated with a vaccine. Remember also that these hefty compensation also pay for the plaintiff legal fees. It would be interesting to have a breakdown of these numbers to see how much goes into legal fees alone.
5. For some patients that are immunocompromised, we cannot give certain vaccines especially live attenuated vaccines. The reason that because of their weakened immune system, there is a small risk that these patient immune system cannot tame these live attenuated viruses, and may have the virus able to overcome their immune system and wreak havoc in their bodies. This is why we have medical exemption, because there are patients that have a legitimacy for not being fully vaccinated.
Please let me know if I can help further, it is hard to condense so many information into a post.
I would also recommend to join Vaccine Talk: A forum for both anti-vaxxers and pro-vaxxers on Facebook. I am a regular there and would be more than happy to discuss more on BBB-related questions.
Thank you :).

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Hello – I found your blog trying to figure out why I still have headaches almost two months after my second dose of the Pfizer vaccine. I had six days of migraine, and then headaches off and on, with only five days since the second dose that have not required medicating the headaches with either ibuprofen or acetaminophen. Any biologically-plausible reason why this would still be happening?

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Hi M, very good question! Have you checked with your doctor about it? Me, and this is my really really big guess (absolutely not a medical advice and ask your healthcare provider) is maybe inherent to your immune response to the vaccine? It seems the immune response vary greatly between indidividual. Me on the Moderna I have almost nothing much than mildly painful shoulder on the second shot. I have some colleagues, getting the same batch, be done like a fever for a couple of days and back up as normal.

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