About Me

My name is Abraham but everybody calls me “Abe”. I am a biologist by heart and neurovascular biologist by mind. I blog everything about that I consider an interest to share and I want to give my opinion on sciences, science-fiction/horror, videogames and so on….

Please feel free to share my news and dont hesitate to leave any comments.

Thank you 🙂



17 thoughts on “About Me

  1. Hi Abe,
    My 15 mo nephew has been recently diagnosed in Rotterdam with Allan-Herndon-Dudley syndrome. To say that we’re completely smitten and have no idea where to turn to is an understatement. You’re mentioning working with Svendsen Lab at Cedar-Sinai. Is the research on AHDS still going on? Any success & breakthroughs? I mean, I read the paper about zebrafish, don’t know, I’m an accountant by trade so for me it doesn’t seem to be of much help to my nephew… Is there any other lab or center in the whole world involved in the research for AHDS?
    There are some clinics in Lebanon, Germany & China that list AHDS among the conditions treatable via stem cells treatment. In your honest expertise, how viable is their claim? Thanks a lot!
    Best regards,

    I’m totally with you on “Elan”!! 🙂

    Liked by 1 person

  2. Hi! I’m so sorry, I’ll bug you again with my AHDS story. You’ve been super helpful and straightforward when you answered my first post and no good deed is left unpunished :)!

    We’re still waiting for the ok for joining the Rotterdam Triac trial, nothing to do with people over there but more with local handling of the issue ( my nephew lives in Greece but the trial will be deployed to Bucharest so happy-happy-joy-joy in Balkans style ). This is not a total loss of time because my sister had some time to adjust to the idea and to do lots, but I mean lots of research on the net and to get in touch with various specialists including nutrition, endocrinology physiotherapy and so on.
    We also got in touch with people who are administering Triac to their kids either inside or outside the trial and the feedback was quite mixed in terms of opinions some of them claiming that there is no improvement whatsoever in their kids status. I mean I know it is not a miracle drug but I was at least expected a more positive outcome.
    So now to the question. Is it possible that in fact the way of being given to the kids ( oral ingestion ) may account for the reason for the lack of improvement in their condition because lot of the active ingredient is lost along the way before even reaching the BBB?
    The reason I’m asking is because of these links/studies:
    Would either of this 2 means of getting the hormones inside the body be a doable endeavor in the case of the “artificial” hormones in Triac in order to get them quicker to BBB instead of ingesting them? And if yes, what would it take and be needed to develop such procedures?

    Thanks a lot, really:) !!


    • Hi Laura,
      Thank you for your message. First of all, I am glad you were able to get your nephew into a clinical trial and what I can say now is to cross my fingers that it works. Entering clinical trials is like entering a dark maze: we know where we came from, we know that should be an exit somewhere but there are plenty of dead-ends that can get us stuck and have to move backwards.
      I have moved away from the AHDS field as I had to focus my research interests in my lab (I am focusing on stroke research and other neurological diseases with a genetic defect at the BBB) but I remember some groups working on developing a synthetic version of the thyroid hormone that can bypass the defective MCT8 and enter the BBB. There are different ways you can bypass the BBB and the intranasal has been a new venue for delivering peptides and bigger cargo inside the brain, some results are fairly optimistic. There are others that try to use vectors to deliver contents across the BBB and finally there is still one method thats works but also the most invasive and the most risky: the intraventricular injection.
      TRIAC is the synthetic one (avoiding the MCT8) and the early clinical trial will tell us how much cross the BBB (based on much is injected) and adjust the dosing. Again, safety is first and a direct injection can be devastating and lethal. By increasing the dose, we may have some entering the BBB and accessing the brain.
      Finally the hardest part is the randomized double-blind studies. There are two groups: one receiving the placebo (a sugar pill) and one receiving the sugar pill with the TRIAC. But neither the patient or the doctor knows who is on what. This is frustrating but also very important because we can have an objective conclusion rather that having a confirmation bias and see improvement because we want to see it whereas there is not.
      At this point, I can just say good luck, wait and see. Clinical trials are like tortuous dark maze. We came from a bright entrance and know there is an exit somewhere. But there are plenty of dead-end corridors and we may spend a lot time getting stuck there.
      Good luck!


    • Hi Jamie-Lee, it was a pleasure to list your band. I had this in the making for a while and thought July 14th would be a great day to promote metal bands from the “francophonie”. i know it is an amateur blog but I believe there is nothing small and good bands should be promoted. Good luck with your tour 🙂


  3. Hi Abe! 🙂 I’m Kirsten, singer of Evig Natt (Eternal Night) and I was wondering if you’d be interested in checking out our latest release? Maybe give us a shout on your blog? If so, let me know what e-mail I can use to send you a promo kit! Hope to hear from you! Kind regards Kx


  4. Hello Abe:

    It was recommended to me that I contact you regarding Mercy Isle and our recently released album “Undying Fire.”

    The album was released on 21.October.2016, coinciding with Metal Female Voices Fest XIII in Belgium and our performance there on 23.October.

    Would you at all be interested in downloading our EPK and mp3 album? If so please feel free to email me at mercyisle@gmail.com.

    Contact name: Kassandra Novell
    Band name: Mercy Isle
    Country/location: USA-Netherlands
    Album name: Undying Fire
    Release date: 21.October.2016
    Label: unsigned
    Genre: Rock/Symphonic Metal
    Similar artists: Trillium, Delain
    Preview site/website: http://www.mercyisle.com
    Related video link (album trailer): https://www.youtube.com/watch?v=DSbGIf5kY4M


    Kassandra Novell
    Mercy Isle (Vocalist)

    E-mail: mercyisle@gmail.com

    Website: http://www.mercyisle.com

    Social media:



  5. Hello Abe, how are you?
    My name is Drake Chrisdensen, I am the Tenor of the Epic Symphonic Metal band Ruins of Elysium (www.facebook.com/RuinsOfElysium).
    We will release our new album Seeds Of Chaos And Serenity on April 4th and I would like to know if you would be available to listen and review it. I’ve seen your review of Mercy Isle’s Undying Fire and I really liked it. Please, send me an email at ruinsofelysiumofficial@gmail.com and I will forward you links to download the full album.
    Here is the link to the lyric video of Serpentarius, first single from Seeds Of Chaos And Serenity: https://www.youtube.com/watch?v=9vyvPkz9cLo

    About the band:

    Name: Ruins of Elysium
    Location: Brazil/Italy
    Album name: Seeds Of Chaos And Serenity
    Release date: 4.April.2017
    Label: unsigned
    Genre: Epic Symphonic/Power Metal
    Similar artists: Versailles, Rhapsody of Fire, Xandria
    Social Media links:

    Thank you so much for your time.

    All the best,


  6. I found your comments about aluminium and the BBB with the connection of vaccines. You seem to debunk the theory that aluminium can cross the BBB and also appear to state that AZT also does not cross the BBB…unless I have misunderstood. I disagree with both of those opinions and have seen an abundance of scientific evidence that both have been shown to pass the BBB.

    Liked by 2 people

    • Hi J. Thanks for your comment. Well what I can say are there are some inconstancies in your claims in regards of what you mention and what is on my blogs. So to not get into an argument, I propose we sort it out, by referring back to the main post I have on Al in vaccines.
      1. “You seem to debunk the theory that aluminium can cross the BBB”. I certainly not said that, such claims came from the VP post that was claiming Al was entering the brain via macrophages. My answer to that claim was the following “A critic I have with his statement is how the author can exclude that Al3+ cannot cross the blood-brain barrier (BBB)? I will talk about the BBB later but I wanted to mention this logical fallacy. We just discussed about the neurotoxic effects of aluminum in the CNS, using Al(Cl)3.”. I mentioned the case of toxicological studies assessing the neurotoxicity of Al via ingestion of AlCl3. Remember, this is AlCl3 not Al(OH)3. We cannot compare oranges to apples but we can compare to the endpoint that is free Al circulating in plasma.
      2. “and also appear to state that AZT also does not cross the BBB…unless I have misunderstood” AZT? Never mentioned of AZT. If you are mentioning AZT for azidothymidine, then yes there are some studies outside highlighting the low permeability of this drug at the BBB. It seems it is not exclusive to this antiviral drug but other kind as well (ritonavir comes in my mind). I would argue the reason of such poor permeability maybe due to their interactions with efflux pumps such as P-gp or BCRP at the BBB. If you are interested, you can look at this study on AZT below.
      3. I thought it was clear in my blog post and if it is not I will make it clear here. Al cross the BBB (probably via the DMT carrier, that is involved in bivalent cation metals). What matters is how much is in the blood plasma. As I said in my blog post, Al neurotoxicity is to be considered when you have constant IV infusion (during total parenteral nutrition) with Al-containing IV bags, especially when you have immature kidneys or have a serious kidney condition. The FDA set the miminum toxic dose to 5mg/kg/day.
      For AZT, since I have not mentioned anything I cannot rebuke anything. I would say that my current understanding is antiviral drugs have probably a low penetration across the BBB but this would require some literature search that I would be happy to help on.

      Liked by 1 person

  7. I just want to respectfully say that you aren’t very well informed on the subject. Maybe you should do some research before making such difinative statements about essential oils. I trust nih and the research that exists a lot more than your so-called expert opinion. Herbs and essential oils have been used medicinally dating back to Bible times as well as ancient civilizations. In fact it used to be the only medicine we had before scientists and synthetic medications became available. We don’t need science to tell us that lavender essential oil immediately takes the sting out of bug bites or that tea tree oil helps acne and scalp issues. Or that eucalyptus can make respiratory issues feel better. Please do some research maybe you will have a different opinion. You are scaring people away from something that some of them can benefit from. All due respect intended.


    • Hmmmm…you know telling that to a pharmacologist that has done his master thesis on polyphenols and their biological activity is the least to say interesting. You made some good points but also still a lot of mistakes.
      1. You claim essential oils have been used back in the Bible times. Where to do you put that? On the Ancient Testament? Lets be conservative, lets say 5000 B.C.? I may argue that maybe EOs are even older than that and maybe as old as mankind and the first hominids. What we call pharmacy today is what what we used to call shamanism and sorcery as mankind learnt to interact with his/her environment. I guess a lot of error and trials (with fatalities) led us to develop what we call today the Pharmacopea. We are still discovering new molecules from fungi and recently marine products. But it is still a hell of chemical synthesis to produce natural compounds as simple as morphine (that is looking fairly simple in terms of structures, there are some very exotic structures out there that make you enjoy if you like organic chemistry).
      2. Indeed we need science to tell us which compound out of the secondary metabolism harbor the anti-inflammatory and analgesic properties. This is done via an old discipline of pharmacy called pharmacognosy and despite not being taught anymore is very useful to link plant biology and pharmacology. As you can see it in this reference, we dont have one but over 40 compounds present in lavender EO (https://www.academicjournals.org/article/article1380119091_Hui%2520et%2520al.pdf). Some of them will soothe, some of them may indeed aggravate the symptoms. This is why it is important to know their composition and their pharmacological activity alone or in combination.
      3. Eucalyptol is a very interesting molecule, in particular with its odd epoxy group. At small dose and applied in a nebulizer, it will act as a mucolytic making you breath better (think about Vicks VapoRub, the classic OTC stuff you buy in winter). But if you apply too much or provide it in the wrong route, you can die from CNS depression (that will shut down your brain respiratory centers and die from asphyxia. This is probably why it is not indicated for children lesser than 2 years).
      (source: https://toxnet.nlm.nih.gov/cgi-bin/sis/search/a?dbs+hsdb:@term+@DOCNO+991).
      Yep, Mother Nature is a very talented chemist with probably the largest chemical library we will have ever access to mankind. But it does not mean that everything is good, some are very harmful and even fatal. As Paracelsus said: “Everything is poison, nothing is not poison. The dose and only the dose makes it the poison”.


  8. Hello Abe, found your review of Exley’s autism / aluminum paper / experiments and found it very well done. I would love to point the less sound minded to your review. Unfortunately, I can already hear their reply “what are THIS GUY’s qualifications that we should believe him (though your comments were very pointed with regard to *anyone* doing any kind of research/study and the publication regarding finding). I can understand wishing to perhaps keep possible identifying details of your life private given the vindictive and unrelenting nature of internet trolls. That said, would you be able to share a bit more of your credentials? (Ex: “I hold a PhD in nuclear basket weaving and have been conducting experiments and research into the effects of such on marmosets for the last 30 years…”) Thank you very much for considering my request and thank you for your voice of reason sounding out against the barbaric yap of those with an agenda.

    Liked by 1 person

    • Hi Kelly, thank you for your answer.
      Wel, what I can say? I have a BS in Biochemistry and a MS in Pharmacology from France, I have a PhD in Human Physiology and Neuroscience from Switzerland (this month marks my 10th anniversary of my thesis defense of designing a blood-brain barrier in vitro using a 2-D and 3-D cell culture), I have five years as a postdoc in the US in two Tier 1 University ranked in the Top 100 list (Shangai Ranking). I am a tenure-track assistant professor in a School of Pharmacy in Texas. I teach pharmacokinetics and pharmacogenomics to PharmD students, advanced neurosciences to PhD students. I have over 25 peer-reviewed studies out there as a BBB expert, including 6 as a senior author paper. My research focuses on modeling neurological diseases in a dish using induced pluripotent stem cells (iPSCs) with a particular interest in stroke research, Alzheimer’s and GLUT1 deficiency syndrome.
      If you can identify me with these information, then you can easily track my publication record in Pubmed and assess my record as a peer-reviewer for several journals in Publons.
      Sure, Exley is a higher rank when it comes to publication record and academic status, however publishing papers that lack controls, use poor methodology (the morin staining and the subsequent immunofluorescence pictures quality makes the guy that I am enjoying spending hours in the microscope room screaming) would make any graduate student jump in a journal club. Having your belief overcomes the scientific rigor and critical thinking as a scientist, bend the data because they dont fit your narrative or your benefactors agenda (Exley is both sitting in the CMSRI scientific board and getting research fund from them) is very dangerous and violates what you have been taught by your mentors as a grad student and a postdoc.
      If I could have funds to assess Al toxicity at the BBB, I would be more than happy to do that.


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