About Me

My name is Abraham but everybody calls me “Abe”. I am a biologist by heart and neurovascular biologist by mind. I blog everything about that I consider an interest to share and I want to give my opinion on sciences, science-fiction/horror, videogames and so on….

Please feel free to share my news and dont hesitate to leave any comments.

Thank you 🙂

Abe.

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11 thoughts on “About Me

  1. Hi Abe,
    My 15 mo nephew has been recently diagnosed in Rotterdam with Allan-Herndon-Dudley syndrome. To say that we’re completely smitten and have no idea where to turn to is an understatement. You’re mentioning working with Svendsen Lab at Cedar-Sinai. Is the research on AHDS still going on? Any success & breakthroughs? I mean, I read the paper about zebrafish, don’t know, I’m an accountant by trade so for me it doesn’t seem to be of much help to my nephew… Is there any other lab or center in the whole world involved in the research for AHDS?
    There are some clinics in Lebanon, Germany & China that list AHDS among the conditions treatable via stem cells treatment. In your honest expertise, how viable is their claim? Thanks a lot!
    Best regards,
    Laura

    PS
    I’m totally with you on “Elan”!! 🙂

    Liked by 1 person

  2. Hi! I’m so sorry, I’ll bug you again with my AHDS story. You’ve been super helpful and straightforward when you answered my first post and no good deed is left unpunished :)!

    We’re still waiting for the ok for joining the Rotterdam Triac trial, nothing to do with people over there but more with local handling of the issue ( my nephew lives in Greece but the trial will be deployed to Bucharest so happy-happy-joy-joy in Balkans style ). This is not a total loss of time because my sister had some time to adjust to the idea and to do lots, but I mean lots of research on the net and to get in touch with various specialists including nutrition, endocrinology physiotherapy and so on.
    We also got in touch with people who are administering Triac to their kids either inside or outside the trial and the feedback was quite mixed in terms of opinions some of them claiming that there is no improvement whatsoever in their kids status. I mean I know it is not a miracle drug but I was at least expected a more positive outcome.
    So now to the question. Is it possible that in fact the way of being given to the kids ( oral ingestion ) may account for the reason for the lack of improvement in their condition because lot of the active ingredient is lost along the way before even reaching the BBB?
    The reason I’m asking is because of these links/studies:
    http://www.ncbi.nlm.nih.gov/pubmed/25801717?report=abstract
    http://vivirsindolorelsalvador.com/en/procedimientos/bombas-intratecales-de-opiodes/
    Would either of this 2 means of getting the hormones inside the body be a doable endeavor in the case of the “artificial” hormones in Triac in order to get them quicker to BBB instead of ingesting them? And if yes, what would it take and be needed to develop such procedures?

    Thanks a lot, really:) !!
    Regards,
    Laura

    Like

    • Hi Laura,
      Thank you for your message. First of all, I am glad you were able to get your nephew into a clinical trial and what I can say now is to cross my fingers that it works. Entering clinical trials is like entering a dark maze: we know where we came from, we know that should be an exit somewhere but there are plenty of dead-ends that can get us stuck and have to move backwards.
      I have moved away from the AHDS field as I had to focus my research interests in my lab (I am focusing on stroke research and other neurological diseases with a genetic defect at the BBB) but I remember some groups working on developing a synthetic version of the thyroid hormone that can bypass the defective MCT8 and enter the BBB. There are different ways you can bypass the BBB and the intranasal has been a new venue for delivering peptides and bigger cargo inside the brain, some results are fairly optimistic. There are others that try to use vectors to deliver contents across the BBB and finally there is still one method thats works but also the most invasive and the most risky: the intraventricular injection.
      TRIAC is the synthetic one (avoiding the MCT8) and the early clinical trial will tell us how much cross the BBB (based on much is injected) and adjust the dosing. Again, safety is first and a direct injection can be devastating and lethal. By increasing the dose, we may have some entering the BBB and accessing the brain.
      Finally the hardest part is the randomized double-blind studies. There are two groups: one receiving the placebo (a sugar pill) and one receiving the sugar pill with the TRIAC. But neither the patient or the doctor knows who is on what. This is frustrating but also very important because we can have an objective conclusion rather that having a confirmation bias and see improvement because we want to see it whereas there is not.
      At this point, I can just say good luck, wait and see. Clinical trials are like tortuous dark maze. We came from a bright entrance and know there is an exit somewhere. But there are plenty of dead-end corridors and we may spend a lot time getting stuck there.
      Good luck!

      Like

    • Hi Jamie-Lee, it was a pleasure to list your band. I had this in the making for a while and thought July 14th would be a great day to promote metal bands from the “francophonie”. i know it is an amateur blog but I believe there is nothing small and good bands should be promoted. Good luck with your tour 🙂

      Like

  3. Hi Abe! 🙂 I’m Kirsten, singer of Evig Natt (Eternal Night) and I was wondering if you’d be interested in checking out our latest release? Maybe give us a shout on your blog? If so, let me know what e-mail I can use to send you a promo kit! Hope to hear from you! Kind regards Kx

    Like

  4. Hello Abe:

    It was recommended to me that I contact you regarding Mercy Isle and our recently released album “Undying Fire.”

    The album was released on 21.October.2016, coinciding with Metal Female Voices Fest XIII in Belgium and our performance there on 23.October.

    Would you at all be interested in downloading our EPK and mp3 album? If so please feel free to email me at mercyisle@gmail.com.

    Contact name: Kassandra Novell
    Band name: Mercy Isle
    Country/location: USA-Netherlands
    Album name: Undying Fire
    Release date: 21.October.2016
    Label: unsigned
    Genre: Rock/Symphonic Metal
    Similar artists: Trillium, Delain
    Preview site/website: http://www.mercyisle.com
    Related video link (album trailer): https://www.youtube.com/watch?v=DSbGIf5kY4M

    Sincerely,

    Kassandra Novell
    Mercy Isle (Vocalist)

    E-mail: mercyisle@gmail.com

    Website: http://www.mercyisle.com

    Social media:
    https://mercyisle.bandcamp.com/

    https://www.facebook.com/MercyIsle/
    https://twitter.com/mercyisle

    Like

  5. Hello Abe, how are you?
    My name is Drake Chrisdensen, I am the Tenor of the Epic Symphonic Metal band Ruins of Elysium (www.facebook.com/RuinsOfElysium).
    We will release our new album Seeds Of Chaos And Serenity on April 4th and I would like to know if you would be available to listen and review it. I’ve seen your review of Mercy Isle’s Undying Fire and I really liked it. Please, send me an email at ruinsofelysiumofficial@gmail.com and I will forward you links to download the full album.
    Here is the link to the lyric video of Serpentarius, first single from Seeds Of Chaos And Serenity: https://www.youtube.com/watch?v=9vyvPkz9cLo

    About the band:

    Name: Ruins of Elysium
    Location: Brazil/Italy
    Album name: Seeds Of Chaos And Serenity
    Release date: 4.April.2017
    Label: unsigned
    Genre: Epic Symphonic/Power Metal
    Similar artists: Versailles, Rhapsody of Fire, Xandria
    Social Media links:
    http://www.facebook.com/RuinsOfElysium
    http://www.reverbnation.com/ruinsofelysium
    ruinsofelysium.bandcamp.com
    http://www.instagram.com/RuinsOfElysium
    twitter.com/RuinsOfElysium

    Thank you so much for your time.

    All the best,
    Drake

    Like

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