Today is the last day of the ISN-ESN biannual meeting taking place this year in Paris (France). The venue was taking place at the Palais Des Congres near Porte Maillot (right on the periphery of Paris). I thought it was a great place for the venue, first by its location (excentered from inner Paris, giving more affordable options for lodging), but also by hosting a shopping mall in the basement level (with affordable lunch options including a Galeries Gourmandes and a Paul Patisserie). Another special perk was the presence of complimentary coffee during the morning and afternoon session breaks.
The presence of vendors was fairly minimal but the welcome package provided by ISN was fairly nice. It included:
A mug of your choice (I took molecular basis of disease of course),
And a set of 10 RATP tickets allowing you to wander inside Paris when the urge of sightseeing overcomes your thirst of science:
This is a first time I am attending a ISN meeting, following the acceptance of my paper by the Journal of Neurochemistry. It is a small conference (maybe 500 attendees, this is a high estimate) but it does not mean the quality of science was small too. The conference was taking place on four full days (21-24 August) with morning plenary lectures including a senior keynote speaker and a junior keynote speaker, followed by two breakout sessions (one morning, one afternoon) covering different topics including development, gene and genetics, synapses and neurotransmission, molecular basis of diseases, neurodegeneration or cell energetics.
One of the nice thing was this huge crowd-sourced timeline in which attendees could fill it with stickers indicating their first publication in Journal of Neurochemistry, their first enrollment in one of the different societies.
Interesting fact, the first ISN took place in Strasbourg (my hometown) in 1967 and 50 years later, one attendee was still attending the same ISN meeting! Hail to the elders!
Senior keynote lectures were very instructive including a keynote lecture by Pr. Tamas Horvath (Yale University, USA) on the selective depletion of Agouti-gene related protein neurons and its impact on feeding behavior. These neurons are present are very few numbers (3000-6000) but play important role in feeding. The take home message? Resistance (to chocolate cake) is futile!
Another interesting keynote lecture was from Pr. Yoshi Hirabayashi (RIKEN, Japan) on glycolipids, their known impact on Gaucher’s disease and more interestingly their contribution into Parkinson’s disease. One slide to highlight the complexity of the topic is this one summarizing the different types of glycosphingolipids present in mammalian brains. Yes, this will be part of your next biochemistry quiz.
Finally, todays senior keynote lecture by Pr. Giovanna Malluci (Cambridge University, UK) on the importance of unfolded-protein response stress and its contribution to several neurodegenerative diseases (in particular on prion diseases), with the importance of elongation factor 2E (elF2E) as a rescue pathway in neurodegeneration. More interestingly was the description in the second part of the cold-shock response and the contribution of RBM3 as a neuroprotective agent. I was aware of the importance of cold in hypoxia tolerance (drowning in frigid water decreases the gravity of brain injury inflicted by hypoxia compared to warm water) but I was always skeptical on the use of cooling blanket on stroke patients to cool their body down. It seems there is some vestigial molecular pathways initially used in evolutionary adaptation in hibernating animals that maybe still present in non-hibernating animals via RBM3. It would be interesting to see how this pathway cross-talk with the HIF-1 pathway.
Other concurrent sessions were interesting including one on transporters in the CNS (especially one on glutathione handling in astrocytes through MRPs), the importance of TDP-43 in ALS and other diseases, SIRT6 and its importance in neurodegenerative (including the possible involvement of Wnt and HIF-1 pathways), mitochondria bioenergetics and the discussion and debate on mitochondria movements in astrocytes and neurons (with even the discussion on Eng Lo’s paper on mitochondria transfer following stroke injury) or novel aspects of neural development and neurogenesis.
The poster sessions were well designed with the exception of the manned poster sessions. Poster sessions were initially scheduled between the morning and afternoon concurrent sessions but the presence of poster authors was requested only during the evening socials after 6:00PM. By principle, I am done with science by 5:00PM if I have been bathing in since the morning, so I ended up seeing a lot of “empty” posters and wished I could have a chance to chat and talk to the poster authors. I think this is were SfN poster session is more adapted: you have half-day to showcase your poster and have a time period (2 hours) to stand next your poster. Maybe the organizers could take this into account for ISN2019 taking place in Montreal.
Finally, the ISN see themselves through the Neurochemistry consortium as funny people and hell yeah they know how to bring fun with a complimentary funny photomaton booth. Another opportunity for me to let the weird and funny coming out of me 🙂
See you in probably the ASN meeting 2018 in Riverside, CA and ISN2019 in Montreal (Quebec, Canada)!