[Neurosciences/BBB/Stroke] Breaking The Wall: Brain pericytes impairs the BBB integrity following ischemic stroke injury. 

Interesting study, reminds me one of my earlier study. Brain pericytes are a particular cell type with a disputed origin (some think they come from neural crest, some think they come from mesoderm and some think they are mesenchymal stem-cell like cells) that play an important role in the brain and retinal vascular integrity.
Pericytes play an important function by stabilizing vessels and tightening the blood-brain barrier and the blood-retina barrier. Loss of pericytes have been associated with disruption of the retinal barrier in diabetic retinopathy whereas it was associated with leaky vessels and impaired amyloid beta clearance.
Interestingly, pericytes have been also associated with an impaired barrier recovery following stroke injury acceding to this study by Shih and colleagues (http://www.jneurosci.org/…/2016/11/14/JNEUROSCI.2891-16.2016). The mechanism of action is something known as it involves matrix metalloproteinases (MMPs). MMPs are enzymes that cleaves matrix proteins into fragments as well as tight junction proteins. The increase in MMP activity following ischemic stroke injury was known but until now it was mostly associated with astrocytes and endothelial cells. In my previous work, I have demonstrated that pericytes were deleterious to the barrier function following hypoxic stress.

Source: Rogue Cells Leave the BBB Defenseless During Stroke Trending | Labroots | Virtual Events, Webinars and Videos

Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s