[BBB/Alzheimer] Study: Blood-Brain Barrier Leakage in Patients with Early Alzheimer Disease

An interesting article came today by the research group of Walter H. Backes, PhD published in the journal Radiology further strengthen the connection between Alzheimer’s disease pathogenesis and blood-brain barrier (BBB).

In this study, the authors investigated changes in paracellular leakage using gadolinium as a contrast agent and post-processing algorithms. They observed an increased vascular leakage to gadolinum in patients diagnosed with an early stage of AD compared to matched control patients.

This is a fairly observational study but again strengthen the link between BBB dysfunction and AD. Yet the mechanism leading to such dysfunction remains unclear and if such leakage is a cause of AD or rather a consequence of it.

 

Source: Radiology: Blood-Brain Barrier Leakage in Patients with Early Alzheimer Disease

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