An interesting article came today by the research group of Walter H. Backes, PhD published in the journal Radiology further strengthen the connection between Alzheimer’s disease pathogenesis and blood-brain barrier (BBB).
In this study, the authors investigated changes in paracellular leakage using gadolinium as a contrast agent and post-processing algorithms. They observed an increased vascular leakage to gadolinum in patients diagnosed with an early stage of AD compared to matched control patients.
This is a fairly observational study but again strengthen the link between BBB dysfunction and AD. Yet the mechanism leading to such dysfunction remains unclear and if such leakage is a cause of AD or rather a consequence of it.