Schroedinger’s Cat 2: Back from Hell

When I think about something coming back from the grave, I cannot stop imagining Romero’s zombies flesh-eaters or the Walking Dead. Or maybe also Uma’s Thurman escape from the grave in “Kill Bill: Volume 2” (with Morricone “The Arena” soundtrack of course) like this:
http://youtu.be/yZpw8NgL_2M

Now there is also something that everybody that fond of science like, it is the Schroedinger’s cat to describe certain aspect of quantum mechanics: http://en.wikipedia.org/wiki/Schrödinger’s_cat#mediaviewer/File:Schrodingers_cat.svg

I like this aspect of quantum mechanics because its really brings you to the fringe of science and closer to science-fiction. “Sliders” TV series anyone.

Well it seems we had some real “Schroedinger’s Cat” in the news or sort of. According to the news, the cat was hit by a car, was pronounced dead and five days later got out the grave alive and kicking. See the full story here:

http://abcnews.go.com/Lifestyle/zombie-cat-buried-cat-believed-dead-meows-back/story?id=28519513

Blood-Brain Barrier Breakdown in the Aging Human Hippocampus: Neuron

Blood-Brain Barrier Breakdown in the Aging Human Hippocampus: Neuron.

[UPDATE]: Cell’s Neuron journal has this cool feature called “video abstract”:

An exciting paper just published by the Zlokovic lab at the University of South California. Dr. Borislav Zlokovic is a well known Alzheimer’s disease in the field of the blood-brain barrier. Many BBB scientists have been calling neuroscientists for a better share of the neurovascular unit in neurological diseases and until now little have been done to increase the awareness of the dysfunctional blood-brain barrier in neurological diseases. Just have a look at the Society for Neurosciences annual meetings: the BBB is almost absent of it.

The Zlokovic lab have been actively working on better understanding how the BBB integrity is impaired during Alzheimer’s disease.  Last year, the same group showed how ApoE, an apolipoprotein expressed at the BBB played an important role in Abeta toxicity by impairing the parasites. This time, the authors have demonstrated using MRI that the BBB become leaky over time, in particular during aging. More interestingly, it has been described that not all the region were as leaky as others. The hippocampus appeared more prone for such leakage and in particular it seems there is a correlation between cognitive decline impairment and increase vascular leakage of the BBB. This again raise the importance to think about neurological disorders both from as neuron-centric and BBB-centric standpoint. Ignoring one is doom for failure of curing the other one.

[Sciences] The National Academies call for a postdoc overhaul

postdoc_pay

It is not because I am now a faculty member that I do not care about the fate of my former postdoc fellows. Instead, I try to bring awareness and mentoring to my grads and postdoc in my institute about their professional careers and to take their career as importantly as their bench work.

The National Academies just published a report on the postdoc situation. And it is really a call for action or maybe a recall for action, as the previous one was published in…..2000 (that is a century in terms of scientific research). It simply refocus on one obvious thing that many postdoctoral associations and raw numbers have been saying: as the academic career is now the alternative career after a PhD, so do the postdoc should be. I have and many others have experienced the postdoc limbo in which you try to bridge the gap between your position terminated (as the grant ends up) and securing a new (and more stable position).

I agree that postdocs should have a five-year term and for international postdocs like I was it was somehow already the case. Many international postdocs are here on a H1-B worker status, that gives you 5 years, with possibility to an extra year (6 years). But at the end of this period, you will have to leave the United States for one year before re-applying for an H1-B. It is not easy if you are single or married, but if you have a family with kids in the public school system, it becomes a nightmare. Therefore international postdocs have to think now twice. If you are thinking for applying for a green card, the sponsored option that is available with a faculty position is vanishing quickly (as faculty positions are becoming more and more scarce) and industry jobs are simply a no-no (as other private companies, they have to face a yearly quota of H1-B visas and the queue is extremely long). But then, how to deal then with the status of Research Assistant Professor (RAPs)? This kind of non-tenure faculty position is kind of a purgatory for senior postdoc and looks a lot like a sort of adjunct professor position (more fitted to scientist). You lead a research project, write grants but your are on soft money. That means if you run dry on grants, you are out.

I also agree that postdoc mentors have to be hold accountable for their postdoc career. I strongly advice and recommend my students, in addition to getting results, to also think in long term their goals and expectations, even if it means they may not pursue a scientific (or academic) career after the PhD. I just feel it is criminal to hire a graduate student or postdoc to have the research done and dispose them as a piece of old furniture once the grants runs out or when the clock rings. So far, little have been done to hold PIs accountable for such mentoring. Thank God, I have a AAA mentoring during my graduate and postdoc mentoring but other fellows were less lucky than me.

Now it is coming the problematic point. Salary! Right now the NRSA postdoc salary is fixed $42’000. But here is the trick, you don’t have yet the fringes and benefits associated. Thats roughly 33% of the gross salary. So if I have a $75’000/year startup package and decide to hire a postdoc, I will likely have to carve out my grant $56’000 just for the postdoc and thats leave me with $19’000 to pay for supplies and research equipment. The problem that you encounter is when you are a young PI, you have to hire a postdoc to help to run the lab (at a graduate student is never ready to take a project by day 1) to generate preliminary data to apply for early careers (R03 NIH) because nobody will give you money if you cannot show you are capable to have the research proposed up and running. This is also where you can assess if you have negotiated well your offer letter (and nobody teaches you how to negotiate). Once negotiated, it is almost impossible to discuss the terms. Now if as they request $50’000, thats brings a whooping $66’000 of your startup gone for postdoc salary. Good luck to keep your lab running on $9’000 for a whole fiscal year! That means we gonna have to rethink the current funding mechanism (grants for trainings, grant for consumables) and also rethink about if these fringes and benefits should be now included in the indirect costs. But yes, that means this solution is not viable for young investigators as it would simply kill us in the egg.

This is a critical time. Budget has been shrinking, the “ol’ glory days” of postdocs are gone and we have to find a viable alternative to have our research lab innovation wheel keep spinning. It is time that faculty, postdocs, funding agencies and institutions sit together and discuss on a consensus that provide a quality training, a cost-effective and a viable environment for young academics.

You can judge by yourself:

Report Urges Significant Reforms to Improve the Training and Salary of Postdoctoral Researchers 

WASHINGTON — A new report from the National Academy of Sciences, National Academy of Engineering, and Institute of Medicine urges significant changes to improve the postdoctoral training system in the United States. The postdoctoral experience should be refocused to have training and mentoring at its center, the report says. In addition, the salaries of postdoctoral researchers should be increased to reflect more accurately the value of their training and contribution to research.

The report also recommends that graduate students avoid viewing postdoctoral positions as the default next step, given that growth in the number of postdoctoral researchers far exceeds growth in the number of tenure-track jobs to which many of these researchers aspire. Instead, with the assistance of their institutions, graduate students should consider a broad range of scientific career paths, said the committee that wrote the report.

“The demand for junior research workers has boomed in recent decades, but the number of research faculty positions into which the junior researchers might hope to move has not kept pace,” said committee chair Gregory Petsko, Arthur J. Mahon Professor of Neurology and Neuroscience at Weill Cornell Medical College. “The result is a system that has created expectations for academic career advancement that in many – perhaps most — cases cannot be met.”

Concern about the postdoctoral training system has been gnawing at the research community for decades, the report observes. The National Academies produced a report in 2000 that called for reforms to the system.  Some progress has been made since then, the new report notes. For example, many universities have created offices of postdoctoral affairs to provide better services to postdoctoral researchers, and postdoctoral researchers created the National Postdoctoral Association to provide a forum and unified voice for themselves.

Other aspects of postdoctoral training have seen little change. There is no convincing evidence that most postdoctoral researchers are receiving adequate mentoring, and little evidence that universities and mentors are providing adequate information about other types of careers. Salaries, always relatively low, have failed to even keep pace with inflation.

Meanwhile, the percentage of Ph.D.s who pursue postdoctoral training has been growing steadily and broadening from the biomedical and physical sciences to engineering and the social sciences. In the United States, an estimated 60,000 to 100,000 postdoctoral researchers now work in various research fields.

Although the data are not definitive, the average length of time researchers spend in postdoctoral positions seems to be increasing, the report says. Sources of funding have changed as well. The number of postdoctoral fellowships and trainee positions — which provide postdoctoral researchers relative autonomy and recognition — has remained nearly constant for decades, while the number of postdoctoral researchers hired as part of research grants or supported by nonfederal sources has grown dramatically.

Postdoctoral research positions are intended to give young scientists advanced research training with a fixed term of appointment. In reality, the practice of employing postdocs as long-term researchers, with little mentoring and little hope of moving into a career that requires advanced research training, unfortunately seems to be becoming more common, said the committee.

To address problems in the postdoctoral training system, the committee developed recommendations for best practices covering five areas — period of service, title and role, career development, compensation and benefits, and mentoring – along with a sixth recommendation on data collection.

Period of service. Postdoctoral appointments for a researcher should total no more than five years in duration, barring extraordinary circumstances (e.g. family leave, illness). This maximum term should include cumulative postdoctoral research experience. Host institutions should maintain a record of how long a postdoctoral researcher remains in a position and provide that information to funding agencies as part of grant proposals. And to facilitate tracking of postdoctoral researchers, funding agencies could assign each postdoctoral researcher an identifier and keep record of the total length of time any given individual is holding such a position.

Title and role.  In many instances, positions currently occupied by postdoctoral researchers are more appropriately filled by permanent staff scientists (e.g., technicians, research assistant professors, staff scientists, laboratory managers). The title of “postdoctoral researcher” should be applied only to those people who are receiving significant advanced training in research. When the appointment period is completed, the postdoctoral researchers should move on to a permanent position elsewhere or be transitioned internally to a staff position with a different and appropriate designation and salary. Funding agencies should have a consistent designation for “postdoctoral researchers” and require evidence that advanced research training is a component of the postdoctoral experience.  Host institutions should create or identify professional positions for individuals who are conducting research but not receiving training, and they should receive appropriate remuneration, benefits, and privileges.

Career development. Host institutions and mentors should, beginning at the first year of graduate school, make students aware of the wide variety of career paths available for Ph.D. recipients, and explain that postdoctoral positions are intended only for those seeking advanced research training. The postdoctoral position should not be viewed by graduate students or principal investigators as the default step after the completion of doctoral training.

“Training for the Ph.D. degree is an ideal preparation for many different careers, and this recommendation is not meant to suggest that the number of graduate students in the physical, life and social sciences is too great,” said Petsko. “It is vital, however, that information about the full range of such career opportunities be available to all graduate students, and that the institutional culture not imply that careers outside a traditional academic track are in any sense inferior options.”

Compensation and benefits of employment. Current postdoctoral salaries are low, the report says. The study committee considered five different approaches for determining an appropriate minimum salary, and all of them suggest an amount of $50,000 or more. In addition, data reveal that the starting salary for NIH’s National Research Service Award (NRSA) postdoctoral award – currently set at $42,000 for 2014 — has become the de facto standard for many disciplines and at many universities. The NIH should raise the NRSA postdoctoral starting salary to $50,000 (2014 dollars) and adjust it annually for inflation. Postdoctoral salaries should be appropriately higher where regional cost of living, disciplinary norms, and institutional or sector salary scales dictate higher salaries. (Two committee members did not support the recommendation for a prescriptive salary standard; see footnote on p. 6 of report.)

To implement this recommendation, federal agencies should require host institutions to provide documentation of the salary a postdoctoral researcher will receive with all grant proposals. Professional societies should collect data on salaries for all positions and make these publicly available.

Mentoring. The postdoctoral experience should have training and mentoring at its center, the report stresses. Host institutions should create provisions that encourage postdoctoral scholars to seek advice, either formally or informally, from multiple advisers, in addition to their immediate supervisor. Host institutions and funding agencies should take responsibility for ensuring the quality of mentoring through training programs for the mentors and evaluation of their performance. Funding agencies should identify better ways of evaluating or rewarding mentoring as an essential component of research. Professional societies are in an ideal position to provide additional mentors to supplement those at host institutions.

Data collection. Current data on the postdoctoral population, in terms of demographics, career aspirations, and career outcomes are neither adequate nor timely. Every institution that employs postdoctoral researchers should collect data on the number of currently employed postdoctoral researchers and where they go after completing their research training, and make this information publicly available. The National Science Foundation should serve as the primary curator for establishing and updating a database system that tracks postdoctoral researchers, including non-academic and foreign-trained postdoctoral researchers.

The study was sponsored by the Presidents’ Committee of the National Academy of Sciences, National Academy of Engineering, and Institute of Medicine; the Alfred P. Sloan Foundation; and the Burroughs Wellcome Fund. The National Academy of Sciences, National Academy of Engineering, Institute of Medicine, and National Research Council make up the National Academies.  They are private, independent nonprofit institutions that provide science, technology, and health policy advice under a congressional charter granted to NAS in 1863.  The National Research Council is the principal operating arm of the National Academy of Sciences and the National Academy of Engineering.  For more information, visit http://national-academies.org.  A committee roster follows.

Contacts:

Sara Frueh, Media Relations Officer

Christina Anderson, Media Relations Assistant

Office of News and Public Information

202-334-2138; e-mail news@nas.edu

http://national-academies.com/newsroom

Twitter: @NAS_news and @NASciences

RSS feed: http://www.nationalacademies.org/rss/index.html

Flickr: http://www.flickr.com/photos/nationalacademyofsciences/sets

Pre-publication copies of The Postdoctoral Experience Revisited are available from the National Academies Press on the Internet at http://www.nap.edu or by calling 202-334-3313 or 1-800-624-6242. Reporters may obtain a copy from the Office of News and Public Information (contacts listed above).

NATIONAL ACADEMY OF SCIENCES

NATIONAL ACADEMY OF ENGINEERING

INSTITUTE OF MEDICINE

Committee on Science, Engineering, and Public Policy

Committee to Review the State of Postdoctoral Experience in Scientists and Engineers

Gregory A. Petsko1,2 (chair)

Arthur J. Mahon Professor of Neurology and Neuroscience, and

Director

Appel Alzheimer’s Disease Research Institute

Weill Cornell Medical College; and

Gyula and Katica Tauber Professor of Biochemistry and Chemistry Emeritus

Brandeis University

New York City

Sibby Anderson-Thompkins

Director of Postdoctoral Affairs

Office of the Vice Chancellor for Research

University of North Carolina

Chapel Hill

  1. Russell Bernard2

Professor Emeritus

Department of Anthropology

University of Florida

Gainesville

Carol Greider1,2

Daniel Nathans Professor and Director

Department of Molecular Biology and Genetics

Johns Hopkins University School of Medicine

Baltimore

James Plummer3

Frederick Emmons Terman Dean

School of Engineering, and

John M. Fluke Professor of Electrical Engineering

Stanford University

Stanford, Calif.

  1. Albert Reece1

Vice President for Medical Affair, ands

Bowers Distinguished Professor and Dean

School of Medicine

University of Maryland

Baltimore

Nancy Schwartz

Professor of Pediatrics and Biochemistry, and

Dean for Postdoctoral Affairs

University of Chicago

Chicago

Paula Stephan

Professor of Economics

Andrew Young School for Policy Studies

Georgia State University

Atlanta

Lorraine Tracey

Medical Science Liaison

Teva Pharmaceuticals

Washington, D.C.

Michael Turner2

Bruce V. and Diana M. Rauner Distinguished Service Professor, and

Director

Kavli Institute for Cosmological Physics

University of Chicago

Chicago

Allison Woodall

Deputy General Counsel

Labor, Employment, and Benefits Group

University of California System

Oakland

Joan Woodard

Former Executive Vice President and Deputy Director

Sandia National Laboratories (retired)

Washington, D.C.

STAFF

Kevin Finneran

Study Director

_________________________________________

1Member, Institute of Medicine

2Member, National Academy of Sciences

3Member, National Academy of Engineering

Charlie-Hebdo terror attack: Those who claimed to act to revenge on Muhammad (PBUH) are indeed impostors

This morning I woke up on a Facebook post of a friend about something tragic happened to Charlie-Hebdo. I was not fond of this journal because he lost its satirical strength and used to work on free provocations to make cash money flows. But I only realized the dramatic outcome of this post by turning on CNN. “Terror Attack on Charlie Hebdo: 12 dead”. Among them five famous caricaturists including Cabu and Wolisnki:Cabu-horizontal Wolinski-at-the-BNF

I grew up with their satiric magazines “Hara-Kiri” or “l’Echo des Savanes”. You have this first shocker, then the second shock is of course to learn the terrorists were Muslims as they yelled “Allah Akbar” and “this is for avenging the Prophet Muhammad (PBUH).”. As a Muslim, I was outraged with this terrorist act brought by former gangsters that usurped my religion for their own interests but also by the killing on the name of the Prophet (PBUH), including Ahmed (42), a Muslim police officer in duty.
In this time of questions, we came back to ask “What the prophet would do?” and brings back the event of Taif. It was a hard time for the Prophet back then, chastised from Mecca and with the loss of his wife Khadijah. He was an outcast of Mecca and turn on the village of Taif to find a community in which he can heal and get accepted. After visiting three chieftains, he got order to leave the town of Taif. During his departure, people of the village mocked, yelled and laughed at him, throwing stones that severely hit him to bleed. Once far enough from Taif he invoked the Almighty: “0, my Allah! To You I complain of the feeble-ness of my strength, of my lack of resources and my being unimportant in the eyes of people. 0, Most Merciful of all those capable of showing mercy! Thou art the Lord of the weak, and Thou art my own Lord. To whom art Thou to entrust me; to an unsympathetic foe who would sullenly frown at me, or to an alien to whom Thou hast given control over my affairs? Not in the least do I care for anything except that I may have Thy protection for myself. I seek shelter in Your light-the light which illuminates the Heavens and dispels all sorts of darkness, and which controls all affairs in this world as well as in the Hereafter. May it never be that I should incur Thy wrath, or that Thou should be displeased with me. I must remove the cause of Thy displeasure till Thou art pleased. There is no strength nor power but through Thee.”.

Moved by this invocation, the archangel Gabriel came to him and asked him if he were seeking revenge on them. The archangel said that it crush the village between two mountains as a punishment or any punishment from the prophet. The prophet replied to it: “Even if these people do not accept Islam, I do hope from Allah that there will be persons from among their progeny who would worship Allah and serve His cause.” 

If Muhammad (PBUH) did not seek revenge on the people that physically and psychological harmed him, who are we to claim revenge on his name? We should indeed ask pity and guidance for those who insult us and try to establish dialogues and break down the fear or misunderstandings but as well hunt down the impostors and lunatics that hijacked our religion for their own self-interests.

I wish my sincere condolences to those who died today from the terror attacks and those who died from the freezing cold in the Middle East by escaping the same criminals that wrecked Syria and Irak havoc.